Reference Report

Reference
Citation	Zeng, Y.A., Rahnama, M., Wang, S., Sosu-Sedzorme, W., Verheyen, E.M. (2007). Drosophila Nemo antagonizes BMP signaling by phosphorylation of Mad and inhibition of its nuclear accumulation. Development 134(11): 2061--2071. (Export to RIS)
FlyBase ID	FBrf0201674
Publication Type	Research paper
PubMed ID	17507407
PubMed Abstract	Drosophila Nemo is the founding member of the Nemo-like kinase (Nlk) family of serine/threonine protein kinases that are involved in several Wnt signal transduction pathways. Here we report a novel function for Nemo in the inhibition of bone morphogenetic protein (BMP) signaling. Genetic interaction studies demonstrate that nemo can antagonize BMP signaling and can inhibit the expression of BMP target genes during wing development. Nemo can bind to and phosphorylate the BMP effector Mad. In cell culture, phosphorylation by Nemo blocks the nuclear accumulation of Mad by promoting export of Mad from the nucleus in a kinase-dependent manner. This is the first example of the inhibition of Drosophila BMP signaling by a MAPK and represents a novel mechanism of Smad inhibition through the phosphorylation of a conserved serine residue within the MH1 domain of Mad.
DOI	10.1242/dev.02853
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Alleles (25)
	Dad^j1E4 dpp^d5 dpp^hr4 dpp^hr56 Mad^{S25A.Scer\UAS} Mad^Scer\UAS.cNa nmo^adk1 nmo^adk2 nmo^{c5-1.Scer\UAS} nmo^DB24 nmo^P1 nmo^Scer\UAS.cUa rl^{Sem.S.Scer\UAS} rl^Sem Scer\GAL4^69B Scer\GAL4^ap-md544 Scer\GAL4^bi.PU Scer\GAL4^dpp.blk1 Scer\GAL4^en-e16E Scer\GAL4^ptc-559.1 Scer\GAL4^vg.int2.1 sog^Scer\UAS.cYa tkv^{Q253D.Scer\UAS.cNb} tkv^Scer\UAS.cUa w^+mC
Constructs (11)
	P{bi-GAL4.U} P{GAL4-dpp.blk1} P{UAS-Mad.N} P{UAS-Mad.S25A} P{UAS-nmo.c5-1} P{UAS-nmo.U} P{UAS-rl^Sem.S} P{UAS-sog.Y} P{UAS-tkv.Q253D.Nb} P{UAS-tkv.U} P{vg(int2.1)-GAL4}
Genes (12)
	Dad dpp Ecol\lacZ Mad nmo rl salm Scer\GAL4 sog tkv vg w
Insertions (4)
	P{en2.4-GAL4}e16E P{GawB}69B P{GawB}ap^md544 P{GawB}ptc^559.1
Natural transposons (1)
	P-element