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Citation
Inoue, Y., Hayashi, S. (2007). Tissue-specific laminin expression facilitates integrin-dependent association of the embryonic wing disc with the trachea in Drosophila.  Dev. Biol. 304(1): 90--101.
FlyBase ID
FBrf0201763
Publication Type
Research paper
Abstract

The interaction of heterologous tissues involves cell adhesion mediated by the extracellular matrix and its receptor integrins. The Drosophila wing disc is an ectodermal invagination that contacts specific tracheal branches at the basolateral cell surface. We show that an alpha subunit of laminin, encoded by wing blister (wb), is essential for the establishment of the interaction between the wing and trachea. During embryogenesis, wing disc cells present Wb at their basolateral surface and extend posteriorly, expanding their association to more posteriorly located tracheal branches. These migratory processes are impaired in the absence of the trachea, Wb, or integrins. Time-lapse and transmission electron microscopy analyses suggest that Wb facilitates integrin-dependent contact over a large surface and controls the cellular behavior of the wing cells, including their exploratory filopodial activity. Our data identify Wb laminin as an extracellular matrix ligand that is essential for integrin-dependent cellular migration in Drosophila.

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PubMed Central ID
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Secondary IDs
  • FBrf0192854
Language of Publication
English
Additional Languages of Abstract
Parent Publication
Publication Type
Journal
Abbreviation
Dev. Biol.
Title
Developmental Biology
Publication Year
1959-
ISBN/ISSN
0012-1606
Data From Reference
Alleles (13)
Genes (13)
Insertions (2)
Transgenic Constructs (4)
Transcripts (1)