Reference Report

Reference
Citation	Lee, S., Cooley, L. (2007). Jagunal is required for reorganizing the endoplasmic reticulum during Drosophila oogenesis. J. Cell Biol. 176(7): 941--952. (Export to RIS)
FlyBase ID	FBrf0201898
Publication Type	Research paper
PubMed ID	17389229
PubMed Abstract	Vesicular traffic in the Drosophila melanogaster oocyte occurs actively during vitellogenesis. Although endocytosis in the oocyte has been well characterized, exocytic vesicular traffic is less well understood. We show that the oocyte endoplasmic reticulum (ER) becomes concentrated into subcortical clusters during vitellogenesis. This ER reorganization requires Jagunal, which is an evolutionarily conserved ER membrane protein. Loss of Jagunal reduces vesicular traffic to the oocyte lateral membrane, but does not affect posterior polarized vesicular traffic, suggesting a role for Jagunal in facilitating vesicular traffic in the subcortex. Reduced membrane traffic caused by loss of Jagunal affects oocyte and bristle growth. We propose that ER reorganization is an important mechanism used by cells to prepare for an increased demand for membrane traffic, and Jagunal facilitates this process through ER clustering.
DOI	10.1083/jcb.200701048
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	J. Cell Biol.
Title	Journal of Cell Biology
Publication Year	1966-
ISBN/ISSN	0021-9525
Data from Reference
Aberrations (1)
	Df(3R)Tpl10
Alleles (21)
	Avic\GFP^Bsg-G00413 Avic\GFP^{EYFP.sqh.T:Hsap\ER,T:Uuuu\KDEL} Avic\GFP^{EYFP.sqh.T:Hsap\Golgi} Avic\GFP^Pdi-ZCL1503 Avic\GFP^{Rtnl1-ZCL1569} Avic\GFP^{Sec61α-ZCL0488} fws^T:Avic\GFP jagn^D16N jagn^K38X jagn^Q21X jagn^R190X jagn^{Scer\UAS.P\T.cLa} jagn^T:Avic\GFP jagn^{T:Avic\GFP-YFP.Venus} jagn^W153X Scer\GAL4^Act5C.PI Scer\GAL4^nos.PG Scer\GAL4^{nos.UTR.T:Hsim\VP16} Scer\GAL4^{otu.T:Hsim\VP16} T:Avic\GFP^YFP.Venus w^+mC
Constructs (11)
	P{Act5C-GAL4} P{fws::GFP} P{GAL4::VP16-nos.UTR} P{GAL4-nos.NGT} P{jagn-GFP.L} P{jagn-Venus.L} P{otu-GAL4::VP16.R} P{PTT-un1} P{sqh-EYFP-ER} P{sqh-EYFP-Golgi} P{UASp-jagn.L}
Genes (12)
	Avic\GFP boca fws hts jagn lva Scer\GAL4 sec5 sec8 T:Avic\GFP w yl
Insertions (4)
	P{PTT-GA}Bsg^G00413 P{PTT-un1}Pdi^ZCL1503 P{PTT-un1}Rtnl1^ZCL1569 P{PTT-un1}Sec61α^ZCL0488
Natural transposons (1)
	P-element