Reference Report

Reference
Citation	Merabet, S., Saadaoui, M., Sambrani, N., Hudry, B., Pradel, J., Affolter, M., Graba, Y. (2007). A unique Extradenticle recruitment mode in the Drosophila Hox protein Ultrabithorax. Proc. Natl. Acad. Sci. U.S.A. 104(43): 16946--16951. (Export to RIS)
FlyBase ID	FBrf0201937
Publication Type	Research paper
PubMed ID	17942685
PubMed Abstract	Hox transcription factors are essential for shaping body morphology in development and evolution. The control of Hox protein activity in part arises from interaction with the PBC class of partners, pre-B cell transcription factor (Pbx) proteins in vertebrates and Extradenticle (Exd) in Drosophila. Characterized interactions occur through a single mode, involving a short hexapeptide motif in the Hox protein. This apparent uniqueness in Hox-PBC interaction provides little mechanistic insight in how the same cofactors endow Hox proteins with specific and diverse activities. Here, we identify in the Drosophila Ultrabithorax (Ubx) protein a short motif responsible for an alternative mode of Exd recruitment. Together with previous reports, this finding highlights that the Hox protein Ubx has multiple ways to interact with the Exd cofactor and suggests that flexibility in Hox-PBC contacts contributes to specify and diversify Hox protein function.
DOI	10.1073/pnas.0705832104
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Proc. Natl. Acad. Sci. U.S.A.
Title	Proceedings of the National Academy of Sciences of the United States of America
Publication Year	1915-
ISBN/ISSN	0027-8424
Data from Reference
Alleles (15)
	Antp::Ubx^{Antp.HX:UC.Scer\UAS} Antp::Ubx^{Antp.HX:UC.UbdA.Scer\UAS} Antp^HX.Scer\UAS Antp^Scer\UAS.cMa Ecol\lacZ^DME Ecol\lacZ^salm.1.1 Ecol\lacZ^salm.328 Ecol\lacZ^vg.806 Scer\GAL4^arm.PS Scer\GAL4^Bx-MS1096 Scer\GAL4^how-24B Ubx^HX.Scer\UAS Ubx^{HX.UbdA.Scer\UAS} Ubx^Scer\UAS.cCa Ubx^{UbdA.Scer\UAS}
Constructs (13)
	P{DME-lacZ} P{GAL4-arm.S} P{salm-lacZ.1.1} P{salm-lacZ.328} P{UAS.Antp.HX:UC} P{UAS-Antp.HX:UC.UbdA} P{UAS-Antp.HX} P{UAS-Antp.M} P{UAS-Ubx.HX.UbdA} P{UAS-Ubx.HX} P{UAS-Ubx.Ia.C} P{UAS-Ubx.UbdA} P{vg(806)-lacZ}
Genes (11)
	abd-A Antp Antp::Ubx Dll dpp Ecol\lacZ exd hth Scer\GAL4 tsh Ubx
Insertions (2)
	P{GawB}Bx^MS1096 P{GawB}how^24B
Natural transposons (1)
	P-element