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Reference
Citation
Stoleru, D., Nawathean, P., Fernandez, M.P., Menet, J.S., Ceriani, M.F., Rosbash, M. (2007). The Drosophila circadian network is a seasonal timer.  Cell 129(1): 207--219.
FlyBase ID
FBrf0202062
Publication Type
Research paper
Abstract

Previous work in Drosophila has defined two populations of circadian brain neurons, morning cells (M-cells) and evening cells (E-cells), both of which keep circadian time and regulate morning and evening activity, respectively. It has long been speculated that a multiple oscillator circadian network in animals underlies the behavioral and physiological pattern variability caused by seasonal fluctuations of photoperiod. We have manipulated separately the circadian photoentrainment pathway within E- and M-cells and show that E-cells process light information and function as master clocks in the presence of light. M-cells in contrast need darkness to cycle autonomously and dominate the network. The results indicate that the network switches control between these two centers as a function of photoperiod. Together with the different entraining properties of the two clock centers, the results suggest that the functional organization of the network underlies the behavioral adjustment to variations in daylength and season.

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PubMed Central ID
Related Publication(s)
Note

A blend of two circadian clocks, seasoned to perfection.
Edery, 2007, Cell 129(1): 21--23 [FBrf0201484]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference
    Alleles (10)
    Genes (7)
    Physical Interactions (1)
    Insertions (1)
    Transgenic Constructs (8)