Reference Report

Reference
Citation	Kankel, M.W., Hurlbut, G.D., Upadhyay, G., Yajnik, V., Yedvobnick, B., Artavanis-Tsakonas, S. (2007). Investigating the genetic circuitry of mastermind in Drosophila, a notch signal effector. Genetics 177(4): 2493--2505. (Export to RIS)
FlyBase ID	FBrf0202064
Publication Type	Research paper
PubMed ID	18073442
PubMed Abstract	Notch signaling regulates multiple developmental processes and is implicated in various human diseases. Through use of the Notch transcriptional co-activator mastermind, we conducted a screen for Notch signal modifiers using the Exelixis collection of insertional mutations, which affects approximately 50% of the Drosophila genome, recovering 160 genes never before associated with Notch, extending the previous roster of genes that interact functionally with the Notch pathway and mastermind. As the molecular identity for most recovered genes is known, gene ontology (GO) analysis was applied, grouping genes according to functional classifications. We identify novel Notch-associated GO categories, uncover nodes of integration between Notch and other signaling pathways, and unveil groups of modifiers that suggest the existence of Notch-independent mastermind functions, including a conserved ability to regulate Wnt signaling.
DOI	10.1534/genetics.107.080994
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (1)
	Df(1)N-54l9
Alleles (51)
	arm^S44Y.GMR arm^S56F.GMR bon^c00454 Bx^d01047 c02134^c02134 CG4612^d03727 CG8090^c06331 CG9119^d01997 CG14767^c06428 cp309^d03908 cp309^d10223 cp309^d11666 crp^d04745 d00627^d00627 d00992^d00992 d01629^d01629 d05123^d05123 d11677^d11677 dl^d05894 dx¹⁵² Eip75B^d08364 esg^d05415 f06222^f06222 fng^d08885 kek1^d03841 klu^d00059 lark¹ lark^d04807 mam² mam^N.Scer\UAS mam^sAX8 Mrp4^d05358 msi¹ msi² mts^c02035 N^55e11 N^Ax-16 N^nd-3 Oaz^d09084 orb2^BG02373 orb^dec rpr^d11052 sca^d09400 Scer\GAL4^bbg-C96 Sin3A^d07432 sm¹ sm⁰⁵³³⁸ sm^KG03875 spen^AH393 spen^XFM911 Xrp1^d04790
Constructs (3)
	P{GMR-arm^S44Y} P{GMR-arm^S56F} P{UAS-mamN}
Genes (91)
	ara arm bon brat Bx c02134 cad caup CG3262 CG4612 CG7370 CG7443 CG8090 CG9119 CG9603 CG14767 CG15166 CG15167 CG42684 Cnot4 corto cp309 crp CycA CycE d00627 d00992 d01629 d05123 d11677 dan Dl dl dpn dve dx ed Eip75B emc esg eyg f06222 fng fz heph insc kek1 kis klu knrl kuz lark mam mirr Mrp4 msi mts N net Nf1 nmo Nrt numb Oaz orb orb2 osa Pcd PGRP-LC pita pnt puc pyd Ras85D rg rpr sca Scer\GAL4 Scm sgg simj Sin3A sm spen stg sty Syp tara Ubx wg Xrp1
Insertions (34)
	P{GawB}bbg^C96 P{XP}Bx^d01047 P{XP}CG4612^d03727 P{XP}CG5793^d01997 P{XP}CG9119^d01997 P{XP}cp309^d03908 P{XP}cp309^d10223 P{XP}cp309^d11666 P{XP}crp^d04745 P{XP}d00627^d00627 P{XP}d00992^d00992 P{XP}d01629^d01629 P{XP}d01997b P{XP}d05123^d05123 P{XP}d11677^d11677 P{XP}dl^d05894 P{XP}Eip75B^d08364 P{XP}esg^d05415 P{XP}fng^d08885 P{XP}kek1^d03841 P{XP}klu^d00059 P{XP}lark^d04807 P{XP}Mrp4^d05358 P{XP}Oaz^d09084 P{XP}rpr^d11052 P{XP}sca^d09400 P{XP}Sin3A^d07432 P{XP}Xrp1^d04790 PBac{PB}bon^c00454 PBac{PB}c02134^c02134 PBac{PB}CG8090^c06331 PBac{PB}CG14767^c06428 PBac{PB}mts^c02035 PBac{WH}f06222^f06222