Open Close
Reference
Citation
Kankel, M.W., Hurlbut, G.D., Upadhyay, G., Yajnik, V., Yedvobnick, B., Artavanis-Tsakonas, S. (2007). Investigating the genetic circuitry of mastermind in Drosophila, a notch signal effector.  Genetics 177(4): 2493--2505.
FlyBase ID
FBrf0202064
Publication Type
Research paper
Abstract
Notch signaling regulates multiple developmental processes and is implicated in various human diseases. Through use of the Notch transcriptional co-activator mastermind, we conducted a screen for Notch signal modifiers using the Exelixis collection of insertional mutations, which affects approximately 50% of the Drosophila genome, recovering 160 genes never before associated with Notch, extending the previous roster of genes that interact functionally with the Notch pathway and mastermind. As the molecular identity for most recovered genes is known, gene ontology (GO) analysis was applied, grouping genes according to functional classifications. We identify novel Notch-associated GO categories, uncover nodes of integration between Notch and other signaling pathways, and unveil groups of modifiers that suggest the existence of Notch-independent mastermind functions, including a conserved ability to regulate Wnt signaling.
PubMed ID
PubMed Central ID
PMC2219471 (PMC) (EuropePMC)
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genetics
    Title
    Genetics
    Publication Year
    1916-
    ISBN/ISSN
    0016-6731
    Data From Reference
    Aberrations (1)
    Alleles (51)
    Genes (91)
    Insertions (34)
    Transgenic Constructs (3)