Reference Report

Reference
Citation	Ting, C.Y., Herman, T., Yonekura, S., Gao, S., Wang, J., Serpe, M., O'Connor, M.B., Zipursky, S.L., Lee, C.H. (2007). Tiling of R7 axons in the Drosophila visual system is mediated both by transduction of an activin signal to the nucleus and by mutual repulsion. Neuron 56(5): 793--806. (Export to RIS)
FlyBase ID	FBrf0202108
Publication Type	Research paper
PubMed ID	18054857
PubMed Abstract	The organization of neuronal wiring into layers and columns is a common feature of both vertebrate and invertebrate brains. In the Drosophila visual system, each R7 photoreceptor axon projects within a single column to a specific layer of the optic lobe. We refer to the restriction of terminals to single columns as tiling. In a genetic screen based on an R7-dependent behavior, we identified the Activin receptor Baboon and the nuclear import adaptor Importin-alpha3 as being required to prevent R7 axon terminals from overlapping with the terminals of R7s in neighboring columns. This tiling function requires the Baboon ligand, dActivin, the transcription factor, dSmad2, and retrograde transport from the growth cone to the R7 nucleus. We propose that dActivin is an autocrine signal that restricts R7 growth cone motility, and we demonstrate that it acts in parallel with a paracrine signal that mediates repulsion between R7 terminals.
DOI	10.1016/j.neuron.2007.09.033
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Neuron
Title	Neuron
Publication Year	1988-
ISBN/ISSN	0896-6273
Data from Reference
Alleles (21)
	Actβ^CM.Scer\UAS Actβ^{dsRNA.HL.Scer\UAS} babo⁹ babo⁵² babo^a.Scer\UAS babo^b.Scer\UAS Gl^Δ.Scer\UAS Kap-α3^16-8 Kap-α3^17-76 Kap-α3^D93 Kap-α3^Scer\UAS.cMa Kap-α3^{Scer\UAS.T:Avic\GFP} Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Scer\FLP1^ey.3.5.hs Scer\GAL4^Act5C.PP Scer\GAL4^GMR.PF sev^V1 Smox¹ Smox^{Scer\UAS.T:Hsap\MYC} Smox^{Scer\UAS.T:Zzzz\FLAG} Syt1^{Scer\UAS.T:Avic\GFP-EGFP}
Constructs (14)
	P{ey-FLP.3.5} P{GAL4-Act5C(-FRT).P} P{GAL4-ninaE.GMR} P{UAS-activin-β.CM} P{UAS-activin-β.HL.dsRNA} P{UAS-babo.a} P{UAS-babo.b} P{UAS-FLAG-Smox} P{UAS-Gl^Δ} P{UAS-Kap-α3.GFP} P{UAS-Kap-α3.M} P{UAS-mCD8::GFP.L} P{UAS-Smox.Myc} P{UAS-syt.eGFP}
Genes (16)
	Actβ babo EcR Gl Kap-α3 mav Mmus\Cd8a nrv1 Scer\FLP1 Scer\GAL4 sev Smox Syt1 T:Avic\GFP T:Hsap\MYC T:Zzzz\FLAG
Natural transposons (1)
	P-element