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Citation
Goyal, G., Fell, B., Sarin, A., Youle, R.J., Sriram, V. (2007). Role of mitochondrial remodeling in programmed cell death in Drosophila melanogaster.  Dev. Cell 12(5): 807--816.
FlyBase ID
FBrf0202254
Publication Type
Research paper
Abstract

The role of mitochondria in Drosophila programmed cell death remains unclear, although certain gene products that regulate cell death seem to be evolutionarily conserved. We find that developmental programmed cell death stimuli in vivo and multiple apoptotic stimuli ex vivo induce dramatic mitochondrial fragmentation upstream of effector caspase activation, phosphatidylserine exposure, and nuclear condensation in Drosophila cells. Unlike genotoxic stress, a lipid cell death mediator induced an increase in mitochondrial contiguity prior to fragmentation of the mitochondria. Using genetic mutants and RNAi-mediated knockdown of drp-1, we find that Drp-1 not only regulates mitochondrial fission in normal cells, but mediates mitochondrial fragmentation during programmed cell death. Mitochondria in drp-1 mutants fail to fragment, resulting in hyperplasia of tissues in vivo and protection of cells from multiple apoptotic stimuli ex vivo. Thus, mitochondrial remodeling is capable of modifying the propensity of cells to undergo death in Drosophila.

PubMed ID
PubMed Central ID
PMC1885957 (PMC) (EuropePMC)
Related Publication(s)
Review

Torn to pieces.
Anonymous, 2007, Nature 447(7143): 357 [FBrf0202546]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Dev. Cell
    Title
    Developmental Cell
    Publication Year
    2001-
    ISBN/ISSN
    1534-5807 1878-1551
    Data From Reference
    Genes (2)
    Cell Lines (1)