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Citation
Montrasio, S., Mlodzik, M., Fanto, M. (2007). A new allele uncovers the role of echinus in the control of ommatidial rotation in the Drosophila eye.  Dev. Dyn. 236(10): 2936--2942.
FlyBase ID
FBrf0202297
Publication Type
Research paper
Abstract

The precise orientation of the ommatidia in the Drosophila eye is achieved through a specialized process of cell migration taking place in the third-instar eye imaginal disc when ommatidial clusters rotate by 90 degrees. This process is strictly coordinated with the establishment of planar cell polarity (PCP), but it relies on a specific set of genes that control its mechanism independently from PCP signaling. Recently, the epidermal growth factor receptor (EGFR) pathway has been implicated in determining ommatidial rotation. We have isolated a new allele of echinus, a gene known to control the patterning and number of interommatidial cells. We show that echinus displays defects in the rotation of ommatidia that are not evident until mid-pupal stages, and we propose that echinus action is that of opposing EGFR by an unknown mechanism and that this can explain both its influence in ommatidial rotation and lattice programmed cell death (PCD).

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Dev. Dyn.
    Title
    Developmental Dynamics
    Publication Year
    1992-
    ISBN/ISSN
    1058-8388
    Data From Reference
    Aberrations (4)
    Alleles (18)
    Genes (15)
    Natural transposons (1)
    Insertions (5)
    Transgenic Constructs (1)