Reference Report

Reference
Citation	Montrasio, S., Mlodzik, M., Fanto, M. (2007). A new allele uncovers the role of echinus in the control of ommatidial rotation in the Drosophila eye. Dev. Dyn. 236(10): 2936--2942. (Export to RIS)
FlyBase ID	FBrf0202297
Publication Type	Research paper
PubMed ID	17879315
PubMed Abstract	The precise orientation of the ommatidia in the Drosophila eye is achieved through a specialized process of cell migration taking place in the third-instar eye imaginal disc when ommatidial clusters rotate by 90 degrees. This process is strictly coordinated with the establishment of planar cell polarity (PCP), but it relies on a specific set of genes that control its mechanism independently from PCP signaling. Recently, the epidermal growth factor receptor (EGFR) pathway has been implicated in determining ommatidial rotation. We have isolated a new allele of echinus, a gene known to control the patterning and number of interommatidial cells. We show that echinus displays defects in the rotation of ommatidia that are not evident until mid-pupal stages, and we propose that echinus action is that of opposing EGFR by an unknown mechanism and that this can explain both its influence in ommatidial rotation and lattice programmed cell death (PCD).
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Dev. Dyn.
Title	Developmental Dynamics
Publication Year	1992-
ISBN/ISSN	1058-8388
Data from Reference
Aberrations (4)
	Df(1)ED6712 Df(1)GA102 Df(1)HC244 Df(3L)Ar14-8
Alleles (18)
	aos^rlt bsk² CadN^Δ14 ec¹ ec^EP1343 ec^KG09175 ec^KG10228 ec^spok Ecol\lacZ^svp-07842 Egfr^t1 hep^r75 nmo^E33 pk^pk-sple-13 Rho1^79-3 S^48-5 shg¹ spi²⁵⁹ Vang^x
Constructs (1)
	P{UAS-AT-1.26Q}
Genes (15)
	aos bsk CadN ec Ecol\lacZ Egfr hep nmo pk Rac1 Rho1 S shg spi Vang
Insertions (5)
	P{EP}ec^EP1343 P{PZ}svp⁰⁷⁸⁴² P{SUPor-P}ec^KG09175 P{SUPor-P}ec^KG10228 P{UAS-AT-1.26Q}ec^spok
Natural transposons (1)
	P-element