Reference Report

Reference
Citation	Sevrioukov, E.A., Burr, J., Huang, E.W., Assi, H.H., Monserrate, J.P., Purves, D.C., Wu, J.N., Song, E.J., Brachmann, C.B. (2007). Drosophila Bcl-2 proteins participate in stress-induced apoptosis, but are not required for normal development. genesis 45(4): 184--193. (Export to RIS)
FlyBase ID	FBrf0202360
Publication Type	Research paper
PubMed ID	17417787
PubMed Abstract	Many developing tissues require programmed cell death (PCD) for proper formation. In mice and C. elegans, developmental PCD is regulated by the Bcl-2 family of proteins. Two bcl-2 genes are encoded in the Drosophila genome (debcl/dBorg1/Drob-1/dBok and buffy/dBorg2) and previous RNAi-based studies suggested a requirement for these in embryonic development. However, we report here that, despite the fact that many tissues in fruit flies are shaped by PCD, deletion of the bcl-2 genes does not perturb normal development. We investigated whether the fly bcl-2 genes regulate non-apoptotic processes that require caspases, but found these to be bcl-2 gene-independent. However, irradiation of the mutants demonstrates that DNA damage-induced apoptosis, mediated by Reaper, is blocked by buffy and that debcl is required to inhibit buffy. Our results demonstrate that developmental PCD regulation in the fly does not rely upon the Bcl-2 proteins, but that they provide an added layer of protection in the apoptotic response to stress.
DOI	10.1002/dvg.20279
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Secondary IDs
Language of Publication	English
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Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	genesis
Title	genesis
Publication Year	2000-
ISBN/ISSN	1526-954X 1526-968X
Data from Reference
Aberrations (1)
	Df(3L)H99
Alleles (7)
	Ark^CD4 Buffy^H37 Buffy^Scer\UAS.cSa debcl^E26 debcl^W105 Dredd^EP1412 Scer\GAL4^da.G32
Constructs (2)
	P{GAL4-da.G32} P{UAS-Buffy.S}
Genes (15)
	Ark arm Buffy CG13196 debcl Dredd Fmo-2 futsch His3 Opbp repo rpr Scer\GAL4 wal wg
Insertions (3)
	P{EPgy2}Buffy^EY11259 P{EPgy2}debcl^EY05743 P{lacW}l(2)SH1233^SH1233
Natural transposons (1)
	P-element