Reference Report

Reference
Citation	Chung, S., Kim, S., Yoon, J., Adler, P.N., Yim, J. (2007). The balance between the novel protein target of wingless and the Drosophila Rho-associated kinase pathway regulates planar cell polarity in the Drosophila wing. Genetics 176(2): 891--903. (Export to RIS)
FlyBase ID	FBrf0202398
Publication Type	Research paper
PubMed ID	17409077
PubMed Abstract	Planar cell polarity (PCP) signaling is mediated by the serpentine receptor Frizzled (Fz) and transduced by Dishevelled (Dsh). Wingless (Wg) signaling utilizes Drosophila Frizzled 2 (DFz2) as a receptor and also requires Dsh for transducing signals to regulate cell proliferation and differentiation in many developmental contexts. Distinct pathways are activated downstream of Dsh in Wg- and Fz-signaling pathways. Recently, a number of genes, which have essential roles as downstream components of PCP signaling, have been identified in Drosophila. They include the small GTPase RhoA/Rho1, its downstream effector Drosophila rho-associated kinase (Drok), and a number of genes such as inturned (in) and fuzzy (fy), whose biochemical functions are unclear. RhoA and Drok provide a link from Fz/Dsh signaling to the modulation of actin cytoskeleton. Here we report the identification of the novel gene target of wingless (tow) by enhancer trap screening. tow expression is negatively regulated by Wg signaling in wing imaginal discs, and the balance between tow and the Drok pathway regulates wing-hair morphogenesis. A loss-of-function mutation in tow does not result in a distinct phenotype. Genetic interaction and gain-of-function studies provide evidence that Tow acts downstream of Fz/Dsh and plays a role in restricting the number of hairs that wing cells form.
DOI	10.1534/genetics.106.069021
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (2)
	Df(3L)tow⁷⁵⁴ In(3L)tow^fz
Alleles (45)
	CG10077⁷⁵⁴ ck¹³ ck⁰⁷¹³⁰ Disc\RFP^{DsRedT4.Scer\UAS.T:nls-tra} dsh¹ Ecol\lacZ^tow-4938 fy⁵ fy⁶ fz²⁴ fz³⁰ fz^{arm.T:Avic\GFP-EGFP} fz^f07870 fz^Scer\UAS.cAa fz^tow pan^ΔN.Scer\UAS pk^D Rho1^72O Rho1^Scer\UAS.cMa Rho1^V14.Scer\UAS rok² rok^CAT.Scer\UAS rok^{CAT-KG.Scer\UAS} rok^αTub84B.PW Scer\GAL4^Act5C.PI Scer\GAL4^ap-md544 Scer\GAL4^Bx-MS1096 Scer\GAL4^dpp.blk1 Scer\GAL4^hs.2sev Scer\GAL4^hs.PB Scer\GAL4^ptc-559.1 Scer\GAL4^{Scer\FRT.Act5C} sha^VB13 sqh^AX3 stan^VC31 tow⁷⁵⁴ tow⁴⁹³⁸ tow^{arm.T:Avic\GFP} tow^d02991 tow^fz tow^Scer\UAS.cCa Vang^Tbs42 w^+mC wg^Scer\UAS.cKa zip¹ zip^IIX62
Constructs (18)
	P{Act5C-GAL4} P{arm-fz.GFP} P{arm-tow.GFP} P{AyGAL4} P{GAL4-dpp.blk1} P{GAL4-Hsp70.PB} P{GAL4-Hsp70.sev} P{lacW} P{UAS-fz.A} P{UAS-pan.dTCFΔN} P{UAS-RedStinger} P{UAS-Rho1.Sph} P{UAS-Rho1.V14} P{UAS-rok.CAT} P{UAS-rok.CAT-KG} P{UAS-tow.C} P{UAS-wg.K} P{αTub84B-rok.W}
Genes (23)
	CG10077 ck Disc\RFP Dpse\GA13273 dsh Ecol\lacZ fy fz fz2 pan pk Rho1 rok Scer\GAL4 sha sqh stan T:Avic\GFP tow Vang w wg zip
Insertions (6)
	P{GawB}ap^md544 P{GawB}Bx^MS1096 P{GawB}ptc^559.1 P{lacW}tow⁴⁹³⁸ P{XP}tow^d02991 PBac{WH}fz^f07870
Natural transposons (1)
	P-element