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Citation
Bachleitner, W., Kempinger, L., Wülbeck, C., Rieger, D., Helfrich-Förster, C. (2007). Moonlight shifts the endogenous clock of Drosophila melanogaster.  Proc. Natl. Acad. Sci. U.S.A. 104(9): 3538--3543.
FlyBase ID
FBrf0202399
Publication Type
Research paper
Abstract

The ability to be synchronized by light-dark cycles is a fundamental property of circadian clocks. Although there are indications that circadian clocks are extremely light-sensitive and that they can be set by the low irradiances that occur at dawn and dusk, this has not been shown on the cellular level. Here, we demonstrate that a subset of Drosophila's pacemaker neurons responds to nocturnal dim light. At a nighttime illumination comparable to quarter-moonlight intensity, the flies increase activity levels and shift their typical morning and evening activity peaks into the night. In parallel, clock protein levels are reduced, and clock protein rhythms shift in opposed direction in subsets of the previously identified morning and evening pacemaker cells. No effect was observed on the peripheral clock in the eye. Our results demonstrate that the neurons driving rhythmic behavior are extremely light-sensitive and capable of shifting activity in response to the very low light intensities that regularly occur in nature. This sensitivity may be instrumental in adaptation to different photoperiods, as was proposed by the morning and evening oscillator model of Pittendrigh and Daan. We also show that this adaptation depends on retinal input but is independent of cryptochrome.

PubMed ID
PubMed Central ID
PMC1805525 (PMC) (EuropePMC)
Associated Information
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Secondary IDs
  • FBrf0193484
Language of Publication
English
Additional Languages of Abstract
Parent Publication
Publication Type
Journal
Abbreviation
Proc. Natl. Acad. Sci. U.S.A.
Title
Proceedings of the National Academy of Sciences of the United States of America
Publication Year
1915-
ISBN/ISSN
0027-8424
Data From Reference
Alleles (2)
Genes (4)