Reference Report

Reference
Citation	Besse, F., Mertel, S., Kittel, R.J., Wichmann, C., Rasse, T.M., Sigrist, S.J., Ephrussi, A. (2007). The Ig cell adhesion molecule Basigin controls compartmentalization and vesicle release at Drosophila melanogaster synapses. J. Cell Biol. 177(5): 843--855. (Export to RIS)
FlyBase ID	FBrf0202422
Publication Type	Research paper
PubMed ID	17548512
PubMed Abstract	Synapses can undergo rapid changes in size as well as in their vesicle release function during both plasticity processes and development. This fundamental property of neuronal cells requires the coordinated rearrangement of synaptic membranes and their associated cytoskeleton, yet remarkably little is known of how this coupling is achieved. In a GFP exon-trap screen, we identified Drosophila melanogaster Basigin (Bsg) as an immunoglobulin domain-containing transmembrane protein accumulating at periactive zones of neuromuscular junctions. Bsg is required pre- and postsynaptically to restrict synaptic bouton size, its juxtamembrane cytoplasmic residues being important for that function. Bsg controls different aspects of synaptic structure, including distribution of synaptic vesicles and organization of the presynaptic cortical actin cytoskeleton. Strikingly, bsg function is also required specifically within the presynaptic terminal to inhibit nonsynchronized evoked vesicle release. We thus propose that Bsg is part of a transsynaptic complex regulating synaptic compartmentalization and strength, and coordinating plasma membrane and cortical organization.
DOI	10.1083/jcb.200701111
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	J. Cell Biol.
Title	Journal of Cell Biology
Publication Year	1966-
ISBN/ISSN	0021-9525
Data from Reference
Aberrations (1)
	Df(2L)Exel7034
Alleles (19)
	Avic\GFP^Bsg-G00413 Bsg¹²¹⁷ Bsg^G00413 Bsg^k13638 Bsg^k14308 Bsg^{N.Scer\UAS.T:Avic\GFP} Bsg^{NGG.Scer\UAS.T:Avic\GFP} Bsg^NP3198 Bsg^NP6293 Bsg^Scer\UAS.cBa Bsg^{Δextra.Scer\UAS.T:Avic\GFP} Bsg^{Δextra.Scer\UAS.T:Rnor\CD2,T:Avic\GFP} Bsg^{Δintra.Scer\UAS.T:Avic\GFP} Moe^{GMA.Scer\UAS.T:Avic\GFP-S65T} Scer\GAL4^elav-C155 Scer\GAL4^how-24B Scer\GAL4^Mhc.PW Scer\GAL4^tub.PU Syt1^{Scer\UAS.T:Avic\GFP-EGFP}
Constructs (11)
	P{GAL4-Mhc.W} P{lacW} P{tub-GAL4.U} P{UAS-Bsg.B} P{UAS-Bsg.NGG} P{UAS-Bsg.Δintra} P{UAS-GFP-Bsg.Δextra} P{UAS-GFP-Bsg} P{UAS-GFP-Bsg-CD2.Δextra} P{UAS-GMA} P{UAS-syt.eGFP}
Genes (15)
	Avic\GFP brp Bsg Csp dlg1 futsch GluRIID Moe Scer\GAL4 Syn Syt1 T:Avic\GFP T:Rnor\CD2 WASp α-Spec
Insertions (8)
	P{GawB}Bsg^NP3198 P{GawB}Bsg^NP6293 P{GawB}elav^C155 P{GawB}how^24B P{lacW}Bsg^k13638 P{lacW}Bsg^k14308 P{lacW}Bsg^SH1217 P{PTT-GA}Bsg^G00413
Natural transposons (1)
	P-element