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Reference Report
| Reference | |||
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| Citation | Teleman, A.A., Hietakangas, V., Sayadian, A.C., Cohen, S.M. (2008). Nutritional control of protein biosynthetic capacity by Insulin via Myc in Drosophila. Cell Metab. 7(1): 21--32. (Export to RIS) | ||
| FlyBase ID | FBrf0202738 | ||
| Publication Type | Research paper | ||
| PubMed ID | 18177722 | ||
| PubMed Abstract | Animals use the insulin/TOR signaling pathway to mediate their response to fluctuations in nutrient availability. Energy and amino acids are monitored at the single-cell level via the TOR branch of the pathway and systemically via insulin signaling to regulate cellular growth and metabolism. Using a combination of genetics, expression profiling, and chromatin immunoprecipitation, we examine nutritional control of gene expression and identify the transcription factor Myc as an important mediator of TOR-dependent regulation of ribosome biogenesis. We also identify myc as a direct target of FOXO and provide genetic evidence that Myc has a key role in mediating the effects of TOR and FOXO on growth and metabolism. FOXO and TOR also converge to regulate protein synthesis, acting via 4E-BP and Lk6, regulators of the translation factor eIF4E. This study uncovers a network of convergent regulation of protein biosynthesis by the FOXO and TOR branches of the nutrient-sensing pathway. | ||
| DOI | 10.1016/j.cmet.2007.11.010 | ||
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| Language of Publication | English | ||
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| Publication Type | Journal | ||
| Abbreviation | Cell Metab. | ||
| Title | Cell Metabolism | ||
| Publication Year | 2005- | ||
| ISBN/ISSN | 1550-4131 | ||
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Data from Reference
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| Genes (31)
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