Reference Report

Reference
Citation	Lee, Y., Paik, D., Bang, S., Kang, J., Chun, B., Lee, S., Bae, E., Chung, J., Kim, J. (2008). Loss of spastic paraplegia gene atlastin induces age-dependent death of dopaminergic neurons in Drosophila. Neurobiol. Aging 29(1): 84--94. (Export to RIS)
FlyBase ID	FBrf0202816
Publication Type	Research paper
PubMed ID	17030474
PubMed Abstract	Hereditary spastic paraplegias (HSPs) are human genetic disorders causing increased stiffness and overactive muscle reflexes in the lower extremities. atlastin (atl) is one of the major genes in which mutations result in HSP. We generated a Drosophila model of HSP that has a null mutation in atl. As they aged, atl null flies were paralyzed by mechanical shock such as bumping or vortexing. Furthermore, the flies showed age-dependent degeneration of dopaminergic neurons. These phenotypes were rescued by targeted expression of atl in dopaminergic neurons or feeding L-DOPA or SK&F 38393, an agonist of dopamine receptor. Our data raised the possibility that one of the causes of HSP disease symptoms in human patients with alt mutations is malfunction or degeneration of dopaminergic neurons.
DOI
Related Publication(s)
Supplementary material	Appendix A. Supplementary data. [FBrf0209819]
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Secondary IDs	FBrf0193044
Language of Publication	English
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Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Neurobiol. Aging
Title	Neurobiology of Aging
Publication Year	1980-
ISBN/ISSN	0197-4580
Data from Reference
Alleles (13)
	atl¹ atl^+t13 atl^{R192Q.Scer\UAS} atl^{R214C.Scer\UAS} atl^Scer\UAS.cLa Ecol\lacZ^Scer\UAS.cUa Scer\GAL4^{Cha.Switch.PL} Scer\GAL4^DAT.PL Scer\GAL4^Ddc.PL Scer\GAL4^elav-C155 Scer\GAL4^ple.PF w^+mC Wsck^t13
Constructs (10)
	P{atl^+t13} P{Cha-Switch.L} P{DAT-GAL4.L} P{Ddc-GAL4.L} P{EP} P{ple-GAL4.F} P{UAS-atl.L} P{UAS-atl.R192Q} P{UAS-atl.R214C} P{UAS-lacZ.U}
Genes (7)
	atl Ecol\lacZ orb ple Scer\GAL4 w Wsck
Insertions (2)
	P{EP}atl¹ P{GawB}elav^C155
Natural transposons (1)
	P-element