Reference Report

Reference
Citation	Sasai, N., Kato, Y., Kimura, G., Takeuchi, T., Yamaguchi, M. (2007). The Drosophila jumonji gene encodes a JmjC-containing nuclear protein that is required for metamorphosis. FEBS J. 274(23): 6139--6151. (Export to RIS)
FlyBase ID	FBrf0202834
Publication Type	Research paper
PubMed ID	17970746
PubMed Abstract	Jumonji (Jmj) is a transcriptional repressor that plays important roles in the suppression of cell proliferation and development of various tissues in the mouse. To further clarify the roles of Jmj during development and gain insight into mechanisms of Jmj-mediated transcriptional regulation, we have taken advantage of Drosophila as a model organism. Drosophila Jmj (dJmj) shares high homology with mammalian Jmj in the JmjN, JmjC and AT-rich interaction domains, as well as in the N-terminal repression domain. dJmj localizes to hundreds of euchromatic sites but not to chromocenter heterochromatin on salivary gland polytene chromosomes. In addition, dJmj is excluded from regions stained with an antibody against Ser5-phosphorylated RNA polymerase II, suggesting a function of dJmj in transcriptionally inactive chromatin. Loss of djmj results in larval and pupal lethality with phenotypes similar to those observed in mutants of ecdysone-regulated genes, implying the involvement of dJmj in the repression of gene expression in the ecdysone pathway. Transgenic mouse Jmj mostly colocalizes with dJmj and partially rescues the phenotypes of djmj mutants, indicating that dJmj is a functional homolog of mammalian Jmj. Furthermore, mutation in djmj suppresses position effect variegation of the T(2;3)Sb(V) rearrangement. These findings suggest that dJmj controls expression of developmentally important genes through modification of chromatin into a transcriptionally silenced state.
DOI	10.1111/j.1742-4658.2007.06135.x
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Language of Publication	English
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Publication Type	Journal
Abbreviation	FEBS J.
Title	FEBS Journal
Publication Year	2005-
ISBN/ISSN	1742-464X
Data from Reference
Aberrations (3)
	Df(3L)AC1 In(1)w^m4 T(2;3)Sb^V
Alleles (5)
	Hmt4-20^BG00814 Jarid2^e03131 Jarid2^EY02717 Mmus\Jarid2^{Scer\UAS.T:Zzzz\FLAG} Scer\GAL4^hs.PB
Constructs (2)
	P{GAL4-Hsp70.PB} P{UAS-FLAG-mjmj}
Genes (12)
	Cdk4 CycD CycE Hmt4-20 Jarid2 lid Mmus\Jarid2 RpII215 Sb Scer\GAL4 Su(var)205 T:Zzzz\FLAG
Insertions (2)
	P{EPgy2}Jarid2^EY02717 PBac{RB}Jarid2^e03131
Natural transposons (1)
	P-element