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Nolte, V., Weigel, D., Schlötterer, C. (2008). The impact of shared ancestral variation on hybrid male lethality - a 16 codon indel in the Drosophila simulans Lhr gene.  J. Evol. Biol. 21(2): 551--555.
FlyBase ID
FBrf0202844
Publication Type
Research paper
Abstract

The Lethal hybrid rescue (Lhr) gene causes hybrid male lethality in crosses between Drosophila simulans and D. melanogaster. Lhr(2) is a D. simulans allele, which rescues hybrid males. It has been recently proposed that a 16 codon insertion, which distinguishes the D. melanogaster and the canonical D. simulans allele, and is lacking in Lhr(2), may be responsible for the functional divergence of D. melanogaster and D. simulans Lhr alleles. Here, we show that the Lhr(2) allele lacking the insertion represents an ancestral polymorphism segregating at a moderate frequency in D. simulans. Crosses of D. melanogaster females to males from two D. simulans strains carrying this deletion showed a severe deficiency of viable hybrid males. Our results suggest that the absence of this insertion alone is not sufficient to explain functional differences between D. melanogaster and D. simulans Lhr alleles.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    J. Evol. Biol.
    Title
    Journal of Evolutionary Biology
    Publication Year
    1988-
    ISBN/ISSN
    1010-061X
    Data From Reference
    Genes (1)