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Citation
Schwendemann, A., Matkovic, T., Linke, C., Klebes, A., Hofmann, A., Korge, G. (2008). Hip, an HP1-interacting protein, is a haplo- and triplo-suppressor of position effect variegation.  Proc. Natl. Acad. Sci. U.S.A. 105(1): 204--209.
FlyBase ID
FBrf0203015
Publication Type
Research paper
Abstract
The Drosophila heterochromatin protein 1 (HP1) regulates epigenetic gene silencing and heterochromatin formation by promoting and maintaining chromatin condensation. Here we report the identification and characterization of an HP1-interacting protein (Hip). Hip interacts with HP1 in vitro and is associated with HP1 in vivo. This interaction is mediated by at least three independent but similar HP1-binding modules of the Hip protein. Hip and HP1 completely colocalize in the pericentric heterochromatin, and both haplo- and triplo-dosage mutations act as dominant suppressors of position effect variegation. These findings identify a player in heterochromatinization and suggest that Hip cooperates with HP1 in chromatin remodeling and gene silencing.
PubMed ID
PubMed Central ID
PMC2224187 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Proc. Natl. Acad. Sci. U.S.A.
    Title
    Proceedings of the National Academy of Sciences of the United States of America
    Publication Year
    1915-
    ISBN/ISSN
    0027-8424
    Data From Reference
    Aberrations (3)
    Alleles (5)
    Genes (4)
    Physical Interactions (4)
    Natural transposons (1)
    Insertions (1)
    Transgenic Constructs (1)