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Reference Report
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| Citation | Fanti, L., Perrini, B., Piacentini, L., Berloco, M., Marchetti, E., Palumbo, G., Pimpinelli, S. (2008). The trithorax group and Pc group proteins are differentially involved in heterochromatin formation in Drosophila. Chromosoma 117(1): 25--39. (Export to RIS) | ||
| FlyBase ID | FBrf0203037 | ||
| Publication Type | Research paper | ||
| PubMed ID | 17823810 | ||
| PubMed Abstract | In Drosophila, the Polycomb group and trithorax group proteins play a critical role in controlling the expression states of homeotic gene complexes during development. The common view is that these two classes of proteins bind to the homeotic complexes and regulate transcription at the level of chromatin. In the present work, we tested the involvement of both groups in mitotic heterochromatin formation in Drosophila. Using specific antibodies, we show that some of the tested Pc-G proteins are present in heterochromatin, while all the tested trx-G proteins localize to specific regions of heterochromatin in both mitotic chromosomes and interphase nuclei. We also observed that mutations in trx-G genes are recessive enhancers of position-effect variegation and are able to repress the transcription of heterochromatic genes. These results strongly suggest that trx-G proteins, along with some Pc-G proteins, play an active role in heterochromatin formation in Drosophila. | ||
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| Language of Publication | English | ||
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| Publication Type | Journal | ||
| Abbreviation | Chromosoma | ||
| Title | Chromosoma | ||
| Publication Year | 1939- | ||
| ISBN/ISSN | 0009-5915 | ||
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Data from Reference
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| Genes (20)
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