Reference Report

Reference
Citation	Chen, G.C., Lee, J.Y., Tang, H.W., Debnath, J., Thomas, S.M., Settleman, J. (2008). Genetic interactions between Drosophila melanogaster Atg1 and paxillin reveal a role for paxillin in autophagosome formation. Autophagy 4(1): 37--45. (Export to RIS)
FlyBase ID	FBrf0203068
Publication Type	Research paper
PubMed ID	17952025
PubMed Abstract	Autophagy is a conserved cellular process of macromolecule recycling that involves vesicle-mediated degradation of cytoplasmic components. Autophagy plays essential roles in normal cell homeostasis and development, the response to stresses such as nutrient starvation, and contributes to disease processes including cancer and neurodegeneration. Although many of the autophagy components identified from genetic screens in yeast are well conserved in higher organisms, the mechanisms by which this process is regulated in any species are just beginning to be elucidated. In a genetic screen in Drosophila melanogaster, we have identified a link between the focal adhesion protein paxillin and the Atg1 kinase, which has been previously implicated in autophagy. In mammalian cells, we find that paxillin is redistributed from focal adhesions during nutrient deprivation, and paxillin-deficient cells exhibit defects in autophagosome formation. Together, these findings reveal a novel evolutionarily conserved role for paxillin in autophagy.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Autophagy
Title	Autophagy
Publication Year	2005-
ISBN/ISSN	1554-8627 1554-8635
Data from Reference
Aberrations (1)
	Df(2L)pr-A16
Alleles (26)
	Atg1^{dsRNA.Scer\UAS} Atg1^EP3193 Atg1^K.GMR Atg1^Scer\UAS.cCa Atg1^Δ3D Atg5^{dsRNA.Scer\UAS} Atg7^{dsRNA.Scer\UAS} Atg12^{dsRNA.Scer\UAS} Avic\GFP^{Scer\UAS.T:SV40\nls2} BacA\p35^GMR.PH bs^Scer\UAS.cHa EcR²²⁵ EcR^Q50st EcR^W53st Fak^CG1 Hsap\MAP1LC3B^{Scer\UAS.T:Avic\GFP-EGFP} if^C.Scer\UAS if^k27e mew^M6 mys^G0091b Pax^f03922 Pax^Scer\UAS.cCa Scer\GAL4^32B Scer\GAL4^69B Scer\GAL4^en-e16E Scer\GAL4^ptc-559.1
Constructs (12)
	P{GMR-Atg1.K} P{GMRP35} P{UAS-Atg1.C} P{UAS-Atg1.IR} P{UAS-Atg5.IR} P{UAS-Atg7.IR} P{UAS-Atg12.IR} P{UAS-bs.H} P{UAS-eGFP-huLC3} P{UAS-GFP.nls} P{UAS-if.C} P{UAS-Pax.C}
Genes (16)
	Atg1 Atg5 Atg7 Atg12 Avic\GFP BacA\p35 bs EcR Fak Hsap\MAP1LC3B if mew mys Pax Sap130 Scer\GAL4
Insertions (7)
	P{en2.4-GAL4}e16E P{EP}CG42709^EP3193 P{GawB}32B P{GawB}69B P{GawB}ptc^559.1 P{lacW}mys^G0091b PBac{WH}Pax^f03922
Natural transposons (1)
	P-element