Reference Report

Reference
Citation	Jeong, S., Rebeiz, M., Andolfatto, P., Werner, T., True, J., Carroll, S.B. (2008). The evolution of gene regulation underlies a morphological difference between two Drosophila sister species. Cell 132(5): 783--793. (Export to RIS)
FlyBase ID	FBrf0203102
Publication Type	Research paper
PubMed ID	18329365
PubMed Abstract	Understanding the mechanisms underlying the morphological divergence of species is one of the central goals of evolutionary biology. Here, we analyze the genetic and molecular bases of the divergence of body pigmentation patterns between Drosophila yakuba and its sister species Drosophila santomea. We found that loss of pigmentation in D. santomea involved the selective loss of expression of the tan and yellow pigmentation genes. We demonstrate that tan gene expression was eliminated through the mutational inactivation of one specific tan cis-regulatory element (CRE) whereas the Tan protein sequence remained unchanged. Surprisingly, we identify three independent loss-of-function alleles of the tan CRE in the young D. santomea lineage. We submit that there is sufficient empirical evidence to support the general prediction that functional evolutionary changes at pleiotropic loci will most often involve mutations in their discrete, modular cis-regulatory elements.
DOI	10.1016/j.cell.2008.01.014
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Alleles (25)
	Avic\GFP^{hs.Stinger.T:nls-tra} Avic\GFP^{JT1.t.T:nls-tra} Avic\GFP^{JT2.t.T:nls-tra} Avic\GFP^{JT3.t.T:nls-tra} Avic\GFP^{JT4.t.T:nls-tra} Avic\GFP^{JT5.t.T:nls-tra} Avic\GFP^{t-MSE.A272.Dyak\t.T:nls-tra} Avic\GFP^{t-MSE.A323.Dyak\t.T:nls-tra} Avic\GFP^{t-MSE.Dsan\t.T:nls-tra} Avic\GFP^{t-MSE.Dyak\t.T:nls-tra} Avic\GFP^{t-MSE.T272.C323.Dsan\t.T:nls-tra} Avic\GFP^{t-MSE.T272.Dsan\t.T:nls-tra} Avic\GFP^{t-MSE.t.T:nls-tra} Avic\GFP^{t-MSE.Δ30.Dsan\t.T:nls-tra} Avic\GFP^{t-MSE.Δ212.Dsan\t.T:nls-tra} CG15370^t8.9 CG15370^t10.3 Gr8a^t10.3 Scer\GAL4^pnr-MD237 t⁵ t^+t10.3 t^Scer\UAS.cTa t^tΔMSE y^Scer\UAS.cCa y^unspecified
Constructs (18)
	P{Dsan\t-nEGFP.t-MSE.T272.C323} P{Dsan\t-nEGFP.t-MSE.T272} P{Dsan\t-nEGFP.t-MSE.Δ30} P{Dsan\t-nEGFP.t-MSE.Δ212} P{Dsan\t-nEGFP.t-MSE} P{Dyak\t-nEGFP.t-MSE.A272} P{Dyak\t-nEGFP.t-MSE.A323} P{Dyak\t-nEGFP.t-MSE} P{t^+t10.3} P{t^tΔMSE} P{t-nEGFP.JT1} P{t-nEGFP.JT2} P{t-nEGFP.JT3} P{t-nEGFP.JT4} P{t-nEGFP.JT5} P{t-nEGFP.t-MSE} P{UAS-t.T} P{UAS-y.C}
Genes (11)
	Avic\GFP CG15370 Dsan\t Dsan\y Dyak\t Dyak\y Gr8a Scer\GAL4 t T:nls-tra y
Insertions (1)
	P{GawB}pnr^MD237
Natural transposons (1)
	P-element