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Citation
Harvey, K.F., Mattila, J., Sofer, A., Bennett, F.C., Ramsey, M.R., Ellisen, L.W., Puig, O., Hariharan, I.K. (2008). FOXO-regulated transcription restricts overgrowth of Tsc mutant organs.  J. Cell Biol. 180(4): 691--696.
FlyBase ID
FBrf0203175
Publication Type
Research paper
Abstract

FOXO is thought to function as a repressor of growth that is, in turn, inhibited by insulin signaling. However, inactivating mutations in Drosophila melanogaster FOXO result in viable flies of normal size, which raises a question over the involvement of FOXO in growth regulation. Previously, a growth-suppressive role for FOXO under conditions of increased target of rapamycin (TOR) pathway activity was described. Here, we further characterize this phenomenon. We show that tuberous sclerosis complex 1 mutations cause increased FOXO levels, resulting in elevated expression of FOXO-regulated genes, some of which are known to antagonize growth-promoting pathways. Analogous transcriptional changes are observed in mammalian cells, which implies that FOXO attenuates TOR-driven growth in diverse species.

PubMed ID
PubMed Central ID
PMC2265581 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    J. Cell Biol.
    Title
    Journal of Cell Biology
    Publication Year
    1966-
    ISBN/ISSN
    0021-9525
    Data From Reference
    Genes (19)
    Cell Lines (1)