Reference Report

Reference
Citation	Mandalaywala, N.V., Chang, S., Snyder, R.G., Levendusky, M.C., Voigt, J.M., Dearborn, R.E. (2008). The tumor suppressor, vitamin D3 up-regulated protein 1 (VDUP1), functions downstream of REPO during Drosophila gliogenesis. Dev. Biol. 315(2): 489--504. (Export to RIS)
FlyBase ID	FBrf0204114
Publication Type	Research paper
PubMed ID	18262515
PubMed Abstract	The tumor suppressor, vitamin D(3) up-regulated protein 1 (VDUP1), regulates cell cycle progression by suppressing AP-1-dependent transcription. Loss of VDUP1 activity is associated with tumorigenesis but little is known about VDUP1 regulatory controls or developmental roles. Here we show that the Drosophila homolog of human VDUP1 (dVDUP1) is expressed throughout the nervous system at all stages of development, the first in vivo analysis of VDUP1 expression patterns in the brain. During neurogenesis dVDUP1 expression is transiently down-regulated coincident with neuroblast delamination. Subsequent to expression of the neuronal marker elav, dVDUP1 is up-regulated to varying degrees in developing neurons. In contrast, dVDUP1 expression is both robust and sustained during gliogenesis, and the cis-regulatory region of the dvdup1 gene contains consensus binding sites for the glial fate gene reversed polarity (repo). Expression of dVDUP1 in presumptive glia is lost in embryos deficient for the glial fate genes glial cells missing (gcm) and repo. Conversely, ectopic expression of gcm or repo was sufficient to induce dVDUP1 expression in the nervous system. Taken together, these data suggest a novel role for the dVDUP1 tumor suppressor during nervous system development as a regulatory target for REPO during gliogenesis.
DOI	10.1016/j.ydbio.2008.01.010
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Biol.
Title	Developmental Biology
Publication Year	1959-
ISBN/ISSN	0012-1606
Data from Reference
Aberrations (1)
	Df(3L)Exel6083
Alleles (14)
	gcm^rA87 gcm^Scer\UAS.cJa Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} repo¹ repo^Scer\UAS.cLa Scer\GAL4^71B Scer\GAL4^Act5C.PI Scer\GAL4^c315a Scer\GAL4^elav.PLu Scer\GAL4^repo.PU Scer\GAL4^{Scer\FRT.Act5C} Scer\GAL4^tub.PU Vdup1^Scer\UAS.cMa w^+mC
Constructs (9)
	P{Act5C-GAL4} P{AyGAL4} P{GAL4-elav.L} P{repo-GAL4.U} P{tub-GAL4.U} P{UAS-gcm.J} P{UAS-mCD8::GFP.L} P{UAS-repo.L} P{UAS-Vdup1.M}
Genes (8)
	bi elav gcm Mmus\Cd8a repo Scer\GAL4 Vdup1 w
Insertions (2)
	P{GawB}71B P{GawB}c315a
Natural transposons (1)
	P-element
Transcripts (1)
	Scer\GAL4^c315aRA