Reference Report

Reference
Citation	Chen, P.L., Clandinin, T.R. (2008). The cadherin Flamingo mediates level-dependent interactions that guide photoreceptor target choice in Drosophila. Neuron 58(1): 26--33. (Export to RIS)
FlyBase ID	FBrf0204321
Publication Type	Research paper
PubMed ID	18400160
PubMed Abstract	Quantitative differences in cadherin activity have been proposed to play important roles in patterning connections between pre- and postsynaptic neurons. However, no examples of such a function have yet been described, and the mechanisms that would allow such differences to direct growth cones to specific synaptic targets are unknown. In the Drosophila visual system, photoreceptors are genetically programmed to make a complex, stereotypic set of synaptic connections. Here we show that the atypical cadherin Flamingo functions as a short-range, homophilic signal, passing between specific R cell growth cones to influence their choice of postsynaptic partners. We find that individual growth cones are sensitive to differences in Flamingo activity through opposing interactions between neighboring cells and require these interactions to be balanced in order to extend along the appropriate trajectory.
DOI	10.1016/j.neuron.2008.01.007
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Neuron
Title	Neuron
Publication Year	1988-
ISBN/ISSN	0896-6273
Data from Reference
Alleles (8)
	Scer\GAL4^elav-C155 Scer\GAL4^gcm-rA87.C Scer\GAL4^HLHmδ.0.5 stan^E45 stan^E59 stan^Scer\UAS.cUa stan^unspecified stan^{ΔEX.Scer\UAS}
Constructs (3)
	P{mδ0.5-GAL4} P{UAS-fmi.U} P{UAS-fmi.ΔEX}
Genes (2)
	Scer\GAL4 stan
Insertions (2)
	P{GawB}elav^C155 P{GawB}gcm^rA87.C