Reference Report

Reference
Citation	Wang, Z., Pan, Y., Li, W., Jiang, H., Chatzimanolis, L., Chang, J., Gong, Z., Liu, L. (2008). Visual pattern memory requires foraging function in the central complex of Drosophila. Learn. Mem. 15(3): 133--142. (Export to RIS)
FlyBase ID	FBrf0204617
Publication Type	Research paper
PubMed ID	18310460
PubMed Abstract	The role of the foraging (for) gene, which encodes a cyclic guanosine-3',5'-monophosphate (cGMP)-dependent protein kinase (PKG), in food-search behavior in Drosophila has been intensively studied. However, its functions in other complex behaviors have not been well-characterized. Here, we show experimentally in Drosophila that the for gene is required in the operant visual learning paradigm. Visual pattern memory was normal in a natural variant rover (for(R)) but was impaired in another natural variant sitter (for(S)), which has a lower PKG level. Memory defects in for(S) flies could be rescued by either constitutive or adult-limited expression of for in the fan-shaped body. Interestingly, we showed that such rescue also occurred when for was expressed in the ellipsoid body. Additionally, expression of for in the fifth layer of the fan-shaped body restored sufficient memory for the pattern parameter "elevation" but not for "contour orientation," whereas expression of for in the ellipsoid body restored sufficient memory for both parameters. Our study defines a Drosophila model for further understanding the role of cGMP-PKG signaling in associative learning/memory and the neural circuit underlying this for-dependent visual pattern memory.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Learn. Mem.
Title	Learning and Memory
Publication Year	1994-
ISBN/ISSN	1072-0502
Data from Reference
Aberrations (1)
	Df(2L)ed1
Alleles (18)
	Avic\GFP^Scer\UAS.cUa for^R for^s for^Scer\UAS.cWa for^Scer\UAS.cWb for^Scer\UAS.cWc lilli^189Y lilli^189Y-ΔE lilli^Scer\UAS.cMa Pka-C1^{Scer\UAS.T:Zzzz\FLAG} Scer\GAL4^Aph-4-c232 Scer\GAL4^C5 Scer\GAL4^c205 Scer\GAL4^c819 Scer\GAL4^elav.PLu Scer\GAL4^lilli-189Y Scer\GAL4^{Mef2.247.Switch} Scer\GAL80^ts.αTub84B
Constructs (9)
	P{GAL4-elav.L} P{MB-Switch} P{tubP-GAL80^ts} P{UAS-for.P1.W} P{UAS-for.P2.W} P{UAS-for.P3.W} P{UAS-GFP.U} P{UAS-lilli.M} P{UAS-Pka-C1.FLAG}
Genes (6)
	Avic\GFP for lilli Pka-C1 Scer\GAL4 Scer\GAL80
Insertions (5)
	P{GawB}Aph-4^c232 P{GawB}C5^C5 P{GawB}c205 P{GawB}c819 P{GawB}lilli^189Y
Natural transposons (1)
	P-element