Reference Report

Reference
Citation	LaFerriere, H., Guarnieri, D.J., Sitaraman, D., Diegelmatin, S., Heberlein, U., Zars, T. (2008). Genetic dissociation of ethanol sensitivity and memory formation in Drosophila melanogaster. Genetics 178(4): 1895--1902. (Export to RIS)
FlyBase ID	FBrf0204698
Publication Type	Research paper
PubMed ID	18430923
PubMed Abstract	The ad hoc genetic correlation between ethanol sensitivity and learning mechanisms in Drosophila could overemphasize a common process supporting both behaviors. To challenge directly the hypothesis that these mechanisms are singular, we examined the learning phenotypes of 10 new strains. Five of these have increased ethanol sensitivity, and the other 5 do not. We tested place and olfactory memory in each of these lines and found two new learning mutations. In one case, altering the tribbles gene, flies have a significantly reduced place memory, elevated olfactory memory, and normal ethanol response. In the second case, mutation of a gene we name ethanol sensitive with low memory (elm), place memory was not altered, olfactory memory was sharply reduced, and sensitivity to ethanol was increased. In sum, however, we found no overall correlation between ethanol sensitivity and place memory in the 10 lines tested. Furthermore, there was a weak but nonsignificant correlation between ethanol sensitivity and olfactory learning. Thus, mutations that alter learning and sensitivity to ethanol can occur independently of each other and this implies that the set of genes important for both ethanol sensitivity and learning is likely a subset of the genes important for either process.
DOI	10.1534/genetics.107.084582
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Alleles (7)
	2-10^2-10 5-103^5-103 9-220^9-220 CG31886^3-68 elm^10-110 path^8-47 trbl^3-54
Constructs (1)
	P{GawB}
Genes (15)
	2-10 5-103 9-220 CG31886 elm GLaz l(2)01289 path phtf PQBP1 qvr sca Spt-I trbl Tsp42El
Insertions (10)
	P{GawB}2-10^2-10 P{GawB}4-43 P{GawB}5-103^5-103 P{GawB}9-220^9-220 P{GawB}10-149 P{GawB}CG31886^3-68 P{GawB}elm^10-110 P{GawB}path^8-47 P{GawB}sca^5-120 P{GawB}trbl^3-54