Home
Reference Report
| Reference | |||
|---|---|---|---|
| Citation | Koch, I., Schwarz, H., Beuchle, D., Goellner, B., Langegger, M., Aberle, H. (2008). Drosophila ankyrin 2 is required for synaptic stability. Neuron 58(2): 210--222. (Export to RIS) | ||
| FlyBase ID | FBrf0204749 | ||
| Publication Type | Research paper | ||
| PubMed ID | 18439406 | ||
| PubMed Abstract | Synaptic connections are stabilized through transsynaptic adhesion complexes that are anchored in the underlying cytoskeleton. The Drosophila neuromuscular junction (NMJs) serves as a model system to unravel genes required for the structural remodeling of synapses. In a mutagenesis screen for regulators of synaptic stability, we recovered mutations in Drosophila ankyrin 2 (ank2) affecting two giant Ank2 isoforms that are specifically expressed in the nervous system and associate with the presynaptic membrane cytoskeleton. ank2 mutant larvae show severe deficits in the stability of NMJs, resulting in a reduction in overall terminal size, withdrawal of synaptic boutons, and disassembly of presynaptic active zones. In addition, lack of Ank2 leads to disintegration of the synaptic microtubule cytoskeleton. Microtubules and microtubule-associated proteins fail to extend into distant boutons. Interestingly, Ank2 functions downstream of spectrin in the anchorage of synaptic microtubules, providing the cytoskeletal scaffold that is essential for synaptic stability. | ||
| DOI | 10.1016/j.neuron.2008.03.019 | ||
| Related Publication(s) | |||
Recent Updates
|
|||
| Description |
What does this section display?
This section contains items that were added to this record for each release.
It currently only tracks new links between this FlyBase report and other
FlyBase data classes (e.g. genes, references, stocks) or controlled
vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
This section does not currently display links that were removed or gene model changes.
|
||
| Update Feed |
Click the icon below to subscribe to this FlyBase record and receive updates automatically through your
feed reader.
|
||
| FB2013_03 | |||
| FB2013_02 | |||
| All updates | Click here to see a list of all updates to this record from FB2010_08 and on. | ||
|
Associated Information
|
|||
| Comments | |||
| Associated Files | |||
|
Other Information
|
|||
| Secondary IDs | |||
| Language of Publication | English | ||
| Additional Languages of Abstract | |||
| Also Published As | |||
|
Parent Publication
|
|||
| Publication Type | Journal | ||
| Abbreviation | Neuron | ||
| Title | Neuron | ||
| Publication Year | 1988- | ||
| ISBN/ISSN | 0896-6273 | ||
|
Data from Reference
|
|||
| Aberrations (7)
|
|||
| Alleles (13)
|
|||
| Constructs (5)
|
|||
| Genes (10)
|
|||
| Insertions (3)
|
|||