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Kind, J., Vaquerizas, J.M., Gebhardt, P., Gentzel, M., Luscombe, N.M., Bertone, P., Akhtar, A. (2008). Genome-wide analysis reveals MOF as a key regulator of dosage compensation and gene expression in Drosophila.  Cell 133(5): 813--828.
FlyBase ID
FBrf0204874
Publication Type
Research paper
Abstract

Dosage compensation, mediated by the MSL complex, regulates X-chromosomal gene expression in Drosophila. Here we report that the histone H4 lysine 16 (H4K16) specific histone acetyltransferase MOF displays differential binding behavior depending on whether the target gene is located on the X chromosome versus the autosomes. More specifically, on the male X chromosome, where MSL1 and MSL3 are preferentially associated with the 3' end of dosage compensated genes, MOF displays a bimodal distribution binding to promoters and the 3' ends of genes. In contrast, on MSL1/MSL3 independent X-linked genes and autosomal genes in males and females, MOF binds primarily to promoters. Binding of MOF to autosomes is functional, as H4K16 acetylation and the transcription levels of a number of genes are affected upon MOF depletion. Therefore, MOF is not only involved in the onset of dosage compensation, but also acts as a regulator of gene expression in the Drosophila genome.

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Note

Chromatin proteins do double duty.
Ercan and Lieb, 2008, Cell 133(5): 763--765 [FBrf0204862]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference