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Reference Report
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| Citation | Krajewski, W.A. (2008). Evidence for the nucleosome-disruption process regulated by phosphorylation of 120 kDa protein complex in Drosophila embryo cell-free system. Biochimie 90(3): 534--541. (Export to RIS) | ||
| FlyBase ID | FBrf0204875 | ||
| Publication Type | Research paper | ||
| PubMed ID | 18054339 | ||
| PubMed Abstract | Using cell-free system derived from Drosophila embryos, we found evidence for a regulated nucleosome disruption process, which depends on the phosphorylation status of 120 kDa protein (complex). Dephosphorylation enables the remodeling activity to destabilize nucleosomes, which assume a more accessible structure, possessing increased DNase I sensitivity and high conformational flexibility of DNA; remodeling was more efficient on highly acetylated chromatin templates. This phosphorylation-regulated nucleosome destabilization, acting synergistically with histone acetylation, is discussed as a possible mechanism to provide regulated disrupt of histone-DNA interaction. | ||
| DOI | 10.1016/j.biochi.2007.11.001 | ||
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| Language of Publication | English | ||
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Parent Publication
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| Publication Type | Journal | ||
| Abbreviation | Biochimie | ||
| Title | Biochimie | ||
| Publication Year | 1971- | ||
| ISBN/ISSN | 0300-9084 | ||
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Data from Reference
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| Genes (4)
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