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Citation
Berry, D.L., Baehrecke, E.H. (2008). Autophagy functions in programmed cell death.  Autophagy 4(3): 359--360.
FlyBase ID
FBrf0204916
Publication Type
Note
Abstract

Autophagic cell death is a prominent morphological form of cell death that occurs in diverse animals. Autophagosomes are abundant during autophagic cell death, yet the functional role of autophagy in cell death has been enigmatic. We find that autophagy and the Atg genes are required for autophagic cell death of Drosophila salivary glands. Although caspases are present in dying salivary glands, autophagy is required for complete cell degradation. Further, induction of high levels of autophagy results in caspase-independent autophagic cell death. Our results provide the first in vivo evidence that autophagy and the Atg genes are required for autophagic cell death and confirm that autophagic cell death is a physiological death program that occurs during development.

PubMed ID
PubMed Central ID
PMC2782713 (PMC) (EuropePMC)
DOI
Related Publication(s)
Research paper

Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila.
Berry and Baehrecke, 2007, Cell 131(6): 1137--1148 [FBrf0200408]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Autophagy
    Title
    Autophagy
    Publication Year
    2005-
    ISBN/ISSN
    1554-8627 1554-8635
    Data From Reference