Reference Report

Reference
Citation	Gluderer, S., Oldham, S., Rintelen, F., Sulzer, A., Schütt, C., Wu, X., Raftery, L.A., Hafen, E., Stocker, H. (2008). Bunched, the Drosophila homolog of the mammalian tumor suppressor TSC-22, promotes cellular growth. BMC Dev. Biol. 8(): 10. (Export to RIS)
FlyBase ID	FBrf0205279
Publication Type	Research paper
PubMed ID	18226226
PubMed Abstract	Transforming Growth Factor-beta1 stimulated clone-22 (TSC-22) is assumed to act as a negative growth regulator and tumor suppressor. TSC-22 belongs to a family of putative transcription factors encoded by four distinct loci in mammals. Possible redundancy among the members of the TSC-22/Dip/Bun protein family complicates a genetic analysis. In Drosophila, all proteins homologous to the TSC-22/Dip/Bun family members are derived from a single locus called bunched (bun).We have identified bun in an unbiased genetic screen for growth regulators in Drosophila. Rather unexpectedly, bun mutations result in a growth deficit. Under standard conditions, only the long protein isoform BunA - but not the short isoforms BunB and BunC - is essential and affects growth. Whereas reducing bunA function diminishes cell number and cell size, overexpression of the short isoforms BunB and BunC antagonizes bunA function.Our findings establish a growth-promoting function of Drosophila BunA. Since the published studies on mammalian systems have largely neglected the long TSC-22 protein version, we hypothesize that the long TSC-22 protein is a functional homolog of BunA in growth regulation, and that it is antagonized by the short TSC-22 protein.
DOI	10.1186/1471-213X-8-10
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Language of Publication	English
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Publication Type	Journal
Abbreviation	BMC Dev. Biol.
Title	BMC Developmental Biology
Publication Year	2002
ISBN/ISSN	1471-213X
Data from Reference
Aberrations (3)
	Df(2L)Exel6033 Df(2L)prd1.7 Df(2L)Prl
Alleles (36)
	bun^200B bun⁰⁰²⁵⁵ bun^585RSX bun⁰⁴²³⁰ bun⁰⁶⁹⁰³ bun^A-149B bun^A-211B bun^A.Scer\UAS bun^A-P519L bun^A-Q578X bun^A-Q609X bun^A-Q879X bun^A-Q922X bun^A-Q988X bun^A-R508W bun^B-132A bun^B-181A bun^B.Scer\UAS bun^C-158B bun^C.Scer\UAS bun^GE11969 bun^GE12327 bun^GE12921 bun^GE14917 bun^rI043 bun^unspecified bun^ΔGE12327 S6k^Scer\UAS.cMa Scer\GAL4^Act5C.PU Scer\GAL4^ap-md544 Scer\GAL4^arm.PS Scer\GAL4^Bx-MS1096 Scer\GAL4^C10 Scer\GAL4^da.G32 Scer\GAL4^ey.PH Scer\GAL4^GMR.PF
Constructs (10)
	P{Act5C-GAL4.U} P{EP} P{GAL4-arm.S} P{GAL4-da.G32} P{GAL4-ey.H} P{GAL4-ninaE.GMR} P{UAS-bun.A} P{UAS-bun.B} P{UAS-bun.C} P{UAS-S6k.M}
Genes (3)
	bun S6k Scer\GAL4
Insertions (7)
	P{EP}bun^GE11969 P{EP}bun^GE12327 P{EP}bun^GE12921 P{EP}bun^GE14917 P{GawB}ap^md544 P{GawB}Bx^MS1096 P{GawB}C10
Natural transposons (1)
	P-element