Reference Report

Reference
Citation	Miura, G.I., Roignant, J.Y., Wassef, M., Treisman, J.E. (2008). Myopic acts in the endocytic pathway to enhance signaling by the Drosophila EGF receptor. Development 135(11): 1913--1922. (Export to RIS)
FlyBase ID	FBrf0205365
Publication Type	Research paper
PubMed ID	18434417
PubMed Abstract	Endocytosis of activated receptors can control signaling levels by exposing the receptors to novel downstream molecules or by instigating their degradation. Epidermal growth factor receptor (EGFR) signaling has crucial roles in development and is misregulated in many cancers. We report here that Myopic, the Drosophila homolog of the Bro1-domain tyrosine phosphatase HD-PTP, promotes EGFR signaling in vivo and in cultured cells. myopic is not required in the presence of activated Ras or in the absence of the ubiquitin ligase Cbl, indicating that it acts on internalized EGFR, and its overexpression enhances the activity of an activated form of EGFR. Myopic is localized to intracellular vesicles adjacent to Rab5-containing early endosomes, and its absence results in the enlargement of endosomal compartments. Loss of Myopic prevents cleavage of the EGFR cytoplasmic domain, a process controlled by the endocytic regulators Cbl and Sprouty. We suggest that Myopic promotes EGFR signaling by mediating its progression through the endocytic pathway.
DOI	10.1242/dev.017202
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (1)
	Df(2L)Exel6277
Alleles (19)
	aos^Δ7 btl::Egfr^{Scer\UAS.T:λ\cI-DD} Cbl^F165 Ecol\lacZ^aos-W11 Ecol\lacZ^Dll-01092 Ecol\lacZ^dpp.BS3.0 Hrs^D28 mop^CS.Scer\UAS mop^Scer\UAS.cMa mop^{Scer\UAS.T:Zzzz\FLAG} mop^T482 mop^T612 mop^T862 Rab5^{Scer\UAS.T:Avic\GFP-EGFP} Ras85D^V12.Scer\UAS Scer\GAL4^ap-md544 Scer\GAL4^unspecified sty^Δ5 w^+mC
Constructs (7)
	P{BS3.0} P{UAS-Egfr.λtop} P{UAS-GFP-Rab5} P{UAS-mop.CS} P{UAS-mop.FLAG} P{UAS-mop.M} P{UAS-Ras85D.V12}
Genes (31)
	aos ato bmm btl::Egfr Cbl CG9384 CG13472 CG17173 CycB dor Ecol\lacZ Egfr elav hkb Hrs mop Rab5 Rab7 Rab11 Ras85D rl Scer\GAL4 sens spi spin sty T:Zzzz\FLAG TSG101 Vps28 w wg
Insertions (3)
	P{GawB}ap^md544 P{lwB}aos^W11 P{PZ}Dll⁰¹⁰⁹²
Natural transposons (1)
	P-element