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Call, G.B., Olson, J.M., Chen, J., Villarasa, N., Ngo, K.T., Yabroff, A.M., Cokus, S., Pellegrini, M., Bibikova, E., Bui, C., Cespedes, A., Chan, C., Chan, S., Cheema, A.K., Chhabra, A., Chitsazzadeh, V., Do, M.T., Fang, Q.A., Folick, A., Goodstein, G.L., Huang, C.R., Hung, T., Kim, E., Kim, W., Kim, Y., Kohan, E., Kuoy, E., Kwak, R., Lee, E., Lee, J., Lin, H., Liu, H.C., Moroz, T., Prasad, T., Prashad, S.L., Patananan, A.N., Rangel, A., Rosselli, D., Sidhu, S., Sitz, D., Taber, C.E., Tan, J., Topp, K., Tran, P., Tran, Q.M., Unkovic, M., Wells, M., Wickland, J., Yackle, K., Yavari, A., Zaretsky, J.M., Allen, C.M., Alli, L., An, J., Anwar, A., Arevalo, S., Ayoub, D., Badal, S.S., Baghdanian, A., Baghdanian, A.H., Baumann, S.A., Becerra, V.N., Chan, H.J., Chang, A.E., Cheng, X.A., Chin, M., Chong, F., Crisostomo, C., Datta, S., Delosreyes, A., Diep, F., Ekanayake, P., Engeln, M., Evers, E., Farshidi, F., Fischer, K., Formanes, A.J., Gong, J., Gupta, R., Haas, B.E., Hahm, V., Hsieh, M., Hui, J.Z., Iao, M.L., Jin, S.D., Kim, A.Y., Kim, L.S., King, M., Knudsen-Robbins, C., Kohanchi, D., Kovshilovskaya, B., Ku, A., Kung, R.W., Landig, M.E., Latterman, S.S., Lauw, S.S., Lee, D.S., Lee, J.S., Lei, K.C., Leung, L.L., Lerner, R., Lin, J.Y., Lin, K., Lim, B.C., Lui, C.P., Liu, T.Q., Luong, V., Makshanoff, J., Mei, A.C., Meza, M., Mikhaeil, Y.A., Moarefi, M., Nguyen, L.H., Pai, S.S., Pandya, M., Patel, A.R., Picard, P.D., Safaee, M.M., Salame, C., Sanchez, C., Sanchez, N., Seifert, C.C., Shah, A., Shilgevorkyan, O.H., Singh, I., Soma, V., Song, J.J., Srivastava, N., StaAna, J.L., Sun, C., Tan, D., Teruya, A.S., Tikia, R., Tran, T., Travis, E.G., Trinh, J.D., Vo, D., Walsh, T., Wong, R.S., Wu, K., Wu, Y.W., Yang, N.X., Yeranosian, M., Yu, J.S., Zhou, J.J., Zhu, R.X., Abrams, A., Abramson, A., Amado, L., Anderson, J., Bashour, K., Beyer, E., Bookatz, A., Brewer, S., Buu, N., Calvillo, S., Cao, J., Chan, A., Chan, J., Chang, A., Chang, D., Chang, Y., Chen, Y., Choi, J., Chou, J., Dang, P., Datta, S., Davarifar, A., Deravanesian, A., Desai, P., Fabrikant, J., Farnad, S., Fu, K., Garcia, E., Garrone, N., Gasparyan, S., Gayda, P., Go, S., Goffstein, C., Gonzalez, C., Guirguis, M., Hassid, R., Hermogeno, B., Hong, J., Hong, A., Hovestreydt, L., Hu, C., Huff, D., Jamshidian, F., Jen, J., Kahen, K., Kao, L., Kelley, M., Kho, T., Kim, Y., Kim, S., Kirkpatrick, B., Langenbacher, A., Laxamana, S., Lee, J., Lee, C., Lee, S.Y., Lee, T.S., Lee, T., Lewis, G., Lezcano, S., Lin, P., Luu, T., Luu, J., Marrs, W., Marsh, E., Marshall, J., Min, S., Minasian, T., Minye, H., Misra, A., Morimoto, M., Moshfegh, Y., Murray, J., Nguyen, K., Nguyen, C., Nodado, E., O'Donahue, A., Onugha, N., Orjiakor, N., Padhiar, B., Paul, E., Pavel-Dinu, M., Pavlenko, A., Paz, E., Phaklides, S., Pham, L., Poulose, P., Powell, R., Pusic, A., Ramola, D., Regalia, K., Ribbens, M., Rifai, B., Saakyan, M., Saarikoski, P., Segura, M., Shadpour, F., Shemmassian, A., Singh, R., Singh, V., Skinner, E., Solomin, D., Soneji, K., Spivey, K., Stageberg, E., Stavchanskiy, M., Tekchandani, L., Thai, L., Thiyanaratnam, J., Tong, M., Toor, A., Tovar, S., Trangsrud, K., Tsang, W.Y., Uemura, M., Vollmer, E., Weiss, E., Wood, D., Wu, J., Wu, S., Wu, W., Xu, Q., Yamauchi, Y., Yarosh, W., Yee, L., Yen, G., Banerjee, U. (2007). Genomewide clonal analysis of lethal mutations in the Drosophila melanogaster eye: comparison of the X chromosome and autosomes.  Genetics 177(2): 689--697.
FlyBase ID
FBrf0205369
Publication Type
Research paper
Abstract

Using a large consortium of undergraduate students in an organized program at the University of California, Los Angeles (UCLA), we have undertaken a functional genomic screen in the Drosophila eye. In addition to the educational value of discovery-based learning, this article presents the first comprehensive genomewide analysis of essential genes involved in eye development. The data reveal the surprising result that the X chromosome has almost twice the frequency of essential genes involved in eye development as that found on the autosomes.

PubMed ID
PubMed Central ID
PMC2034635 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genetics
    Title
    Genetics
    Publication Year
    1916-
    ISBN/ISSN
    0016-6731
    Data From Reference
    Genes (1)