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Reference
Citation
Sokol, N.S., Xu, P., Jan, Y.N., Ambros, V. (2008). Drosophila let-7 microRNA is required for remodeling of the neuromusculature during metamorphosis.  Genes Dev. 22(12): 1591--1596.
FlyBase ID
FBrf0205376
Publication Type
Research paper
Abstract

The Drosophila let-7-Complex (let-7-C) is a polycistronic locus encoding three ancient microRNAs: let-7, miR-100, and fly lin-4 (miR-125). We find that the let-7-C locus is principally expressed in the pupal and adult neuromusculature. let-7-C knockout flies appear normal externally but display defects in adult behaviors (e.g., flight, motility, and fertility) as well as clear juvenile features in their neuromusculature. We find that the function of let-7-C to ensure the appropriate remodeling of the abdominal neuromusculature during the larval-to-adult transition is carried out predominantly by let-7 alone. This heterochronic role of let-7 is likely just one of the ways in which let-7-C promotes adult behavior.

PubMed ID
PubMed Central ID
PMC2428057 (PMC) (EuropePMC)
Related Publication(s)
Supplementary material
Note

A matter of timing: microRNA-controlled temporal identities in worms and flies.
Frasch, 2008, Genes Dev. 22(12): 1572--1576 [FBrf0205527]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genes Dev.
    Title
    Genes & Development
    Publication Year
    1987-
    ISBN/ISSN
    0890-9369
    Data From Reference
    Aberrations (2)
    Alleles (12)
    Genes (8)
    Natural transposons (1)
    Insertions (2)
    Experimental Tools (1)
    Transgenic Constructs (8)