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Citation
Casso, D.J., Liu, S., Iwaki, D.D., Ogden, S.K., Kornberg, T.B. (2008). A screen for modifiers of hedgehog signaling in Drosophila melanogaster identifies swm and mts.  Genetics 178(3): 1399--1413.
FlyBase ID
FBrf0205418
Publication Type
Research paper
Abstract
Signaling by Hedgehog (Hh) proteins shapes most tissues and organs in both vertebrates and invertebrates, and its misregulation has been implicated in many human diseases. Although components of the signaling pathway have been identified, key aspects of the signaling mechanism and downstream targets remain to be elucidated. We performed an enhancer/suppressor screen in Drosophila to identify novel components of the pathway and identified 26 autosomal regions that modify a phenotypic readout of Hh signaling. Three of the regions include genes that contribute constituents to the pathway-patched, engrailed, and hh. One of the other regions includes the gene microtubule star (mts) that encodes a subunit of protein phosphatase 2A. We show that mts is necessary for full activation of Hh signaling. A second region includes the gene second mitotic wave missing (swm). swm is recessive lethal and is predicted to encode an evolutionarily conserved protein with RNA binding and Zn(+) finger domains. Characterization of newly isolated alleles indicates that swm is a negative regulator of Hh signaling and is essential for cell polarity.
PubMed ID
PubMed Central ID
PMC2278107 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genetics
    Title
    Genetics
    Publication Year
    1916-
    ISBN/ISSN
    0016-6731
    Data From Reference
    Aberrations (73)
    Alleles (29)
    Gene Groups (1)
    Genes (13)
    Cell Lines (1)
    Natural transposons (1)
    Insertions (8)
    Experimental Tools (3)
    Transgenic Constructs (8)