Open Close
Reference
Citation
Kucherenko, M.M., Pantoja, M., Yatsenko, A.S., Shcherbata, H.R., Fischer, K.A., Maksymiv, D.V., Chernyk, Y.I., Ruohola-Baker, H. (2008). Genetic modifier screens reveal new components that interact with the Drosophila dystroglycan-dystrophin complex.  PLoS ONE 3(6): e2418.
FlyBase ID
FBrf0205440
Publication Type
Research paper
Abstract
The Dystroglycan-Dystrophin (Dg-Dys) complex has a capacity to transmit information from the extracellular matrix to the cytoskeleton inside the cell. It is proposed that this interaction is under tight regulation; however the signaling/regulatory components of Dg-Dys complex remain elusive. Understanding the regulation of the complex is critical since defects in this complex cause muscular dystrophy in humans. To reveal new regulators of the Dg-Dys complex, we used a model organism Drosophila melanogaster and performed genetic interaction screens to identify modifiers of Dg and Dys mutants in Drosophila wing veins. These mutant screens revealed that the Dg-Dys complex interacts with genes involved in muscle function and components of Notch, TGF-beta and EGFR signaling pathways. In addition, components of pathways that are required for cellular and/or axonal migration through cytoskeletal regulation, such as Semaphorin-Plexin, Frazzled-Netrin and Slit-Robo pathways show interactions with Dys and/or Dg. These data suggest that the Dg-Dys complex and the other pathways regulating extracellular information transfer to the cytoskeletal dynamics are more intercalated than previously thought.
PubMed ID
PubMed Central ID
PMC2398783 (PMC) (EuropePMC)
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    PLoS ONE
    Title
    PLoS ONE
    Publication Year
    2006-
    ISBN/ISSN
    1932-6203
    Data From Reference
    Aberrations (21)
    Alleles (61)
    Genes (50)
    Insertions (6)
    Transgenic Constructs (5)