Reference Report

Reference
Citation	Tichy, A.L., Ray, A., Carlson, J.R. (2008). A new Drosophila POU gene, pdm3, acts in odor receptor expression and axon targeting of olfactory neurons. J. Neurosci. 28(28): 7121--7129. (Export to RIS)
FlyBase ID	FBrf0205479
Publication Type	Research paper
PubMed ID	18614681
PubMed Abstract	Olfaction depends on the differential activation of olfactory receptor neurons (ORNs) and on the proper transmission of their activities to the brain. ORNs select individual receptors to express, and they send axons to particular targets in the brain. Little is known about the molecular mechanisms underlying either process. We have identified a new Drosophila POU gene, pdm3, that is expressed in ORNs. Genetic analysis shows that pdm3 is required for odor response in one class of ORNs. We find that pdm3 acts in odor receptor expression in this class, and that the odor response can be rescued by the receptor. Another POU gene, acj6, is required for receptor expression in the same class, and we find a genetic interaction between the two POU genes. The results support a role for a POU gene code in receptor gene choice. pdm3 is also expressed in other ORN classes in which it is not required for receptor expression. For two of these classes, pdm3 is required for normal axon targeting. Thus, this mutational analysis, the first for a POU class VI gene, demonstrates a role for pdm3 in both of the processes that define the functional organization of ORNs in the olfactory system.
DOI	10.1523/JNEUROSCI.2063-08.2008
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Language of Publication	English
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Publication Type	Journal
Abbreviation	J. Neurosci.
Title	Journal of Neuroscience
Publication Year	1981-
ISBN/ISSN	0270-6474 1529-2401
Data from Reference
Aberrations (1)
	Df(2R)Exel6058
Alleles (14)
	acj6⁶ Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Or42a^{Scer\UAS.T:Hsap\MYC} pdm3^f00828 pdm3^{Scer\UAS.long} pdm3^{Scer\UAS.short} Scer\GAL4^acj6-PG63 Scer\GAL4^elav-C155 Scer\GAL4^Or33c.PG Scer\GAL4^Or42a.PG Scer\GAL4^Or46a.PG Scer\GAL4^Or59c.PF Scer\GAL4^Or71a.PG Scer\GAL4^Or85e.PW
Constructs (8)
	P{Or33c-GAL4.G} P{Or42a-GAL4.G} P{Or59c-GAL4.F} P{Or71a-GAL4.G} P{UAS-mCD8::GFP.L} P{UAS-Or42a.MYC} P{UAS-pdm3.long} P{UAS-pdm3.short}
Genes (13)
	acj6 elav Mmus\Cd8a Or33c Or42a Or46a Or59c Or71a Or85c Or85d Or85e pdm3 Scer\GAL4
Insertions (3)
	P{GawB}acj6^PG63 P{GawB}elav^C155 PBac{WH}pdm3^f00828
Natural transposons (1)
	P-element
Transcripts (4)
	Scer\GAL4^Or33c.PGRA Scer\GAL4^Or46a.PGRA Scer\GAL4^Or59c.PFRA Scer\GAL4^Or85e.PGRA