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| Citation | Yang, H.P., Barbash, D.A. (2008). Abundant and species-specific DINE-1 transposable elements in 12 Drosophila genomes. Genome Biol. 9(2): R39. (Export to RIS) | ||
| FlyBase ID | FBrf0205483 | ||
| Publication Type | Research paper | ||
| PubMed ID | 18291035 | ||
| PubMed Abstract | Miniature inverted-repeat transposable elements (MITEs) are non-autonomous DNA-mediated transposable elements (TEs) derived from autonomous TEs. Unlike in many plants or animals, MITEs and other types of DNA-mediated TEs were previously thought to be either rare or absent in Drosophila. Most other TE families in Drosophila exist at low or intermediate copy number (around < 100 per genome).We present evidence here that the dispersed repeat Drosophila interspersed element 1 (DINE-1; also named INE-1 and DNAREP1) is a highly abundant DNA-mediated TE containing inverted repeats found in all 12 sequenced Drosophila genomes. All DINE-1s share a similar sequence structure, but are more homogeneous within species than they are among species. The inferred phylogenetic relationship of the DINE-1 consensus sequence from each species is generally consistent with the known species phylogeny, suggesting vertical transmission as the major mechanism for DINE-1 propagation. Exceptions observed in D. willistoni and D. ananassae could be due to either horizontal transfer or reactivation of ancestral copies. Our analysis of pairwise percentage identity of DINE-1 copies within species suggests that the transpositional activity of DINE-1 is extremely dynamic, with some lineages showing evidence for recent transpositional bursts and other lineages appearing to have silenced their DINE-1s for long periods of time. We also find that all species have many DINE-1 insertions in introns and adjacent to protein-coding genes. Finally, we discuss our results in light of a recent proposal that DINE-1s belong to the Helitron family of TEs.We find that all 12 Drosophila species with whole-genome sequence contain the high copy element DINE-1. Although all DINE-1s share a similar structure, species-specific variation in the distribution of average pairwise divergence suggests that DINE-1 has gone through multiple independent cycles of activation and suppression. DINE-1 also has had a significant impact on gene structure evolution. | ||
| DOI | 10.1186/gb-2008-9-2-r39 | ||
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| Language of Publication | English | ||
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| Publication Type | Journal | ||
| Abbreviation | Genome Biol. | ||
| Title | Genome Biology | ||
| Publication Year | 2000- | ||
| ISBN/ISSN | 1465-6906 | ||
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Data from Reference
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| Natural transposons (12)
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