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Citation
Frasch, M. (2008). A matter of timing: microRNA-controlled temporal identities in worms and flies.  Genes Dev. 22(12): 1572--1576.
FlyBase ID
FBrf0205527
Publication Type
Note
Abstract

The first microRNAs were identified in Caenorhabditis elegans based on their functions in the temporal regulation of stage-specific cell fate decisions. Until now, it was not known whether the so-called heterochronic genes that encode miRNAs are also involved in controlling developmental transitions in other organisms. New findings by Sokol et al. (this issue of Genes & Development, pp. 1591-1596) demonstrate that the Drosophila counterpart of a heterochronic miRNA gene from C. elegans, let-7, does indeed play a role in promoting stage-specific developmental events in neuromuscular tissues during the transition from larval to adult stages, thus pointing to a more widespread utilization of miRNAs in temporal regulation of animal development.

PubMed ID
PubMed Central ID
PMC2732419 (PMC) (EuropePMC)
Related Publication(s)
Research paper

Drosophila let-7 microRNA is required for remodeling of the neuromusculature during metamorphosis.
Sokol et al., 2008, Genes Dev. 22(12): 1591--1596 [FBrf0205376]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genes Dev.
    Title
    Genes & Development
    Publication Year
    1987-
    ISBN/ISSN
    0890-9369
    Data From Reference