Reference Report

Reference
Citation	Li-Kroeger, D., Witt, L.M., Grimes, H.L., Cook, T.A., Gebelein, B. (2008). Hox and senseless antagonism functions as a molecular switch to regulate EGF secretion in the Drosophila PNS. Dev. Cell 15(2): 298--308. (Export to RIS)
FlyBase ID	FBrf0205665
Publication Type	Research paper
PubMed ID	18694568
PubMed Abstract	Hox factors are key regulators of distinct cells, tissues, and organs along the body plan. However, little is known about how Hox factors regulate cell-specific gene expression to pattern diverse tissues. Here, we show an unexpected Hox transcriptional mechanism: the permissive regulation of EGF secretion, and thereby cell specification, by antagonizing the Senseless transcription factor in the peripheral nervous system. rhomboid expression in a subset of sensory cells stimulates EGF secretion to induce hepatocyte-like cell development. We identified a rhomboid enhancer that is active in these cells and show that an abdominal Hox complex directly competes with Senseless for enhancer binding, with the transcriptional outcome dependent upon their relative binding activities. Thus, Hox-Senseless antagonism forms a molecular switch that integrates neural and anterior-posterior positional information. As the vertebrate senseless homolog is essential for neural development as well as hematopoiesis, we propose Hox-Senseless antagonism will broadly control cell fate decisions.
DOI	10.1016/j.devcel.2008.06.001
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Cell
Title	Developmental Cell
Publication Year	2001-
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Data from Reference
Alleles (19)
	abd-A^M1 abd-A^{Scer\UAS.T:Hsap\MYC} Antp^{Scer\UAS.T:Hsap\MYC} ato^Scer\UAS.cJa Avic\GFP^Scer\UAS.cUa Ecol\lacZ^rho.654 Ecol\lacZ^rho.BAD Ecol\lacZ^rho.BADExdM Ecol\lacZ^rho.BADHoxM Ecol\lacZ^rho.BADHthM Ecol\lacZ^rho.BADSensM Ecol\lacZ^{rho.BADSensMHoxM} hth^Meis1-P2 rho^7M43 rho^Scer\UAS.cGa Scer\GAL4^en-e16E Scer\GAL4^prd.RG1 Scer\GAL4^rho.654 sens^E2
Constructs (14)
	P{GAL4-prd.F} P{rho-GAL4.654} P{rho-lacZ.654} P{rho-lacZ.BAD} P{rho-lacZ.BADExdM} P{rho-lacZ.BADHoxM} P{rho-lacZ.BADHthM} P{rho-lacZ.BADSensM} P{rho-lacZ.BADSensMHoxM} P{UAS-abd-A.Myc} P{UAS-Antp.Myc} P{UAS-ato.J} P{UAS-GFP.U} P{UAS-ve.(rho)G}
Genes (13)
	abd-A Antp ato Avic\GFP Ecol\lacZ exd futsch hth rho salm Scer\GAL4 sens T:Hsap\MYC
Insertions (1)
	P{en2.4-GAL4}e16E
Natural transposons (1)
	P-element