Reference Report

Reference
Citation	Root, C.M., Masuyama, K., Green, D.S., Enell, L.E., Nässel, D.R., Lee, C.H., Wang, J.W. (2008). A presynaptic gain control mechanism fine-tunes olfactory behavior. Neuron 59(2): 311--321. (Export to RIS)
FlyBase ID	FBrf0205669
Publication Type	Research paper
PubMed ID	18667158
PubMed Abstract	Early sensory processing can play a critical role in sensing environmental cues. We have investigated the physiological and behavioral function of gain control at the first synapse of olfactory processing in Drosophila. Olfactory receptor neurons (ORNs) express the GABA(B) receptor (GABA(B)R), and its expression expands the dynamic range of ORN synaptic transmission that is preserved in projection neuron responses. Strikingly, each ORN channel has a unique baseline level of GABA(B)R expression. ORNs that sense the aversive odorant CO(2) do not express GABA(B)Rs and do not have significant presynaptic inhibition. In contrast, pheromone-sensing ORNs express a high level of GABA(B)Rs and exhibit strong presynaptic inhibition. Furthermore, pheromone-dependent mate localization is impaired in flies that lack GABA(B)Rs in specific ORNs. These findings indicate that different olfactory receptor channels employ heterogeneous presynaptic gain control as a mechanism to allow an animal's innate behavioral responses to match its ecological needs.
DOI	10.1016/j.neuron.2008.07.003
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Neuron
Title	Neuron
Publication Year	1988-
ISBN/ISSN	0896-6273
Data from Reference
Alleles (14)
	Avic\GFP^{GCaMP1.3.Scer\UAS.cAa} Avic\GFP^{GCaMP.IRES.Ecol\lexAop} Avic\GFP^{pHluorinSE.Scer\UAS.T:Mmus\Vamp2} Crei\ChR2^Scer\UAS.cSa Ecol\lexA^{Orco.T:Hsim\VP16} GABA-B-R2^{dsRNA.Scer\UAS} Mmmm\VR1^{E600K.Scer\UAS} Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Scer\GAL4^GABA-B-R2.PR Scer\GAL4^GH146.PB Scer\GAL4^GH298 Scer\GAL4^Gr21a.9.323 Scer\GAL4^Or47b.PC Scer\GAL4^{Orco.2.642.T:Hsim\VP22}
Constructs (13)
	P{GABA-B-R2-GAL4.R} P{Gr21a-GAL4.9.323} P{LexAop-GCaMP-IRES-GCaMP} P{Or47b-GAL4.C} P{Orco-GAL4.W} P{Orco-LexA-VP16} P{UAS-ChR2.S} P{UAS-GABA-B-R2.RNAi} P{UAS-GCaMP1.3.A} P{UAS-mCD8::GFP.L} P{UAS-synapto-pHluorinSE.Vamp2} P{UAS-VR1E600K} PBac{GH146-GAL4.B}
Genes (14)
	Avic\GFP Crei\ChR2 Ecol\lexA GABA-B-R2 Gr21a Mmmm\VR1 Mmus\Cd8a Or47b Orco Rh4 Scer\GAL4 T:Ggal\MLCK T:Mmus\Vamp2 T:Rat\Cam
Insertions (1)
	P{GawB}GH298
Natural transposons (1)
	P-element
Transcripts (5)
	Ecol\lexA^{Orco.T:Hsim\VP16}RA Scer\GAL4^GABA-B-R2.PRRA Scer\GAL4^Gr21a.9.323RA Scer\GAL4^Or47b.PCRA Scer\GAL4^{Orco.2.642.T:Hsim\VP22}RA