Reference Report

Reference
Citation	Strutt, D., Warrington, S.J. (2008). Planar polarity genes in the Drosophila wing regulate the localisation of the FH3-domain protein Multiple Wing Hairs to control the site of hair production. Development 135(18): 3103--3111. (Export to RIS)
FlyBase ID	FBrf0205732
Publication Type	Research paper
PubMed ID	18701542
PubMed Abstract	The core planar polarity proteins play important roles in coordinating cell polarity, in part by adopting asymmetric subcellular localisations that are likely to serve as cues for cell polarisation by as yet uncharacterised pathways. Here we describe the role of Multiple Wing Hairs (Mwh), a novel formin homology 3 (FH3)-domain protein, which acts downstream of the core polarity proteins to restrict the production of actin-rich prehairs to distal cell edges in the Drosophila pupal wing. Mwh appears to function as a repressor of actin filament formation and, in its absence, ectopic actin bundles are seen across the entire apical surface of cells. We show that the proximally localised core polarity protein Strabismus acts via the downstream effector proteins Inturned, Fuzzy and Fritz to stabilise Mwh in apico-proximal cellular regions. In addition, the distally localised core polarity protein Frizzled positively promotes prehair initiation, suggesting that both proximal and distal cellular cues act together to ensure accurate prehair placement.
DOI	10.1242/dev.025205
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Secondary IDs
Language of Publication	English
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Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (1)
	In(3L)mwh¹
Alleles (15)
	frtz³³ fy² fy^{Act5C.T:Avic\GFP-EGFP} fy^{Scer\FRT.Act5C.T:Avic\GFP-EGFP} fz²¹ in^IH56 mwh¹ mwh^{Act5C.T:Avic\GFP-EGFP} mwh^GD8165 mwh^{Scer\FRT.Act5C.T:Avic\GFP-EGFP} pk^pk-sple-13 Scer\GAL4^ptc-559.1 sha^unspecified T:Avic\GFP^EGFP Vang^stbm-6
Constructs (5)
	P{Act5C(FRT.polyA)EGFP-fy} P{Act5C(FRT.polyA)EGFP-mwh} P{Act5C(-FRT)EGFP-fy} P{Act5C(-FRT)EGFP-mwh} P{GD8165}
Genes (11)
	dsh frtz fy fz in mwh pk Scer\GAL4 sha stan Vang
Insertions (1)
	P{GawB}ptc^559.1
Natural transposons (1)
	P-element