Reference Report

Reference
Citation	Kwon, Y., Shim, H.S., Wang, X., Montell, C. (2008). Control of thermotactic behavior via coupling of a TRP channel to a phospholipase C signaling cascade. Nat. Neurosci. 11(8): 871--873. (Export to RIS)
FlyBase ID	FBrf0205753
Publication Type	Research paper
PubMed ID	18660806
PubMed Abstract	In animals such as the fruitfly, even minor deviations in environmental temperature can have major impacts on development and lifespan. Here we demonstrated that the ability of Drosophila melanogaster larvae to discriminate between the optimal temperature of 18 degrees C and slightly higher temperatures (19-24 degrees C) depended on the TRPA1 channel, which functioned downstream of a phospholipase C-dependent signaling cascade similar to that used in fly phototransduction. We propose that activation of TRPA1 through a signaling cascade promotes amplification of small differences in temperature and facilitates adaptation to temperatures within the comfortable range.
DOI	10.1038/nn.2170
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Nat. Neurosci.
Title	Nature Neuroscience
Publication Year	1998-
ISBN/ISSN	1097-6256
Data from Reference
Alleles (28)
	CdsA¹ Gαq¹ Gαq^{dsRNA.Scer\UAS} iav¹ laza¹ laza^+t.10.35kb Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} nan^36a nompC³ nompC⁴ norpA⁷ norpA³¹ norpA³⁶ norpA^Scer\UAS.ckb pain^EP2621 Pkd2¹ pyx³ rdgA^KS60 rdgC³⁰⁶ rdgC^+t7.0 Scer\GAL4^TrpA1.PR trp⁹ TrpA1¹ TrpA1^Scer\UAS.cKb trpl³⁰² trpml¹ trpγ¹ wtrw¹
Constructs (7)
	P{laza.10.35} P{rdgC} P{TrpA1-GAL4.R} P{UAS-Gα49B-dsRNA} P{UAS-mCD8::GFP.L} P{UAS-norpA.WT} P{UAS-TrpA1.WT}
Genes (20)
	CdsA Gαq iav laza Mmus\Cd8a nan nompC norpA pain Pkd2 pyx rdgA rdgC Scer\GAL4 trp TrpA1 trpl trpml trpγ wtrw