Home
Reference Report
| Reference | |||
|---|---|---|---|
| Citation | Iklé, J., Elwell, J.A., Bryantsev, A.L., Cripps, R.M. (2008). Cardiac expression of the Drosophila Transglutaminase (CG7356) gene is directly controlled by myocyte enhancer factor-2. Dev. Dyn. 237(8): 2090--2099. (Export to RIS) | ||
| FlyBase ID | FBrf0205799 | ||
| Publication Type | Research paper | ||
| PubMed ID | 18627097 | ||
| PubMed Abstract | The myocyte enhancer factor-2 (MEF2) family of transcription factors plays key roles in the activation of muscle structural genes. In Drosophila, MEF2 accumulates at high levels in the embryonic muscles, where it activates target genes throughout the mesoderm. Here, we identify the Transglutaminase gene (Tg; CG7356) as a direct transcriptional target of MEF2 in the cardiac musculature. Tg is expressed in cells forming the inflow tracts of the dorsal vessel, and we identify the enhancer responsible for this expression. The enhancer contains three binding sites for MEF2, and can be activated by MEF2 in tissue culture and in vivo. Moreover, loss of MEF2 function, or removal of the MEF2 binding sites from the enhancer, results in loss of Tg expression. These studies identify a new MEF2 target in the cardiac musculature. These studies provide a possible mechanism for the activation of transglutaminase genes. | ||
| DOI | 10.1002/dvdy.21624 | ||
| Related Publication(s) | |||
Recent Updates
|
|||
| Description |
What does this section display?
This section contains items that were added to this record for each release.
It currently only tracks new links between this FlyBase report and other
FlyBase data classes (e.g. genes, references, stocks) or controlled
vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
This section does not currently display links that were removed or gene model changes.
|
||
| Update Feed |
Click the icon below to subscribe to this FlyBase record and receive updates automatically through your
feed reader.
|
||
| FB2013_03 | |||
| FB2013_02 | |||
| All updates | Click here to see a list of all updates to this record from FB2010_08 and on. | ||
|
Associated Information
|
|||
| Comments | |||
| Associated Files | |||
|
Other Information
|
|||
| Secondary IDs | |||
| Language of Publication | English | ||
| Additional Languages of Abstract | |||
| Also Published As | |||
|
Parent Publication
|
|||
| Publication Type | Journal | ||
| Abbreviation | Dev. Dyn. | ||
| Title | Developmental Dynamics | ||
| Publication Year | 1992- | ||
| ISBN/ISSN | 1058-8388 | ||
|
Data from Reference
|
|||
| Alleles (10)
|
|||
| Constructs (7)
|
|||
| Genes (7)
|
|||
| Natural transposons (3)
|
|||
| Sequence features (1)
|
|||