Reference Report

Reference
Citation	Sprecher, S.G., Pichaud, F., Desplan, C. (2007). Adult and larval photoreceptors use different mechanisms to specify the same Rhodopsin fates. Genes Dev. 21(17): 2182--2195. (Export to RIS)
FlyBase ID	FBrf0205916
Publication Type	Research paper
PubMed ID	17785526
PubMed Abstract	Although development of the adult Drosophila compound eye is very well understood, little is known about development of photoreceptors (PRs) in the simple larval eye. We show here that the larval eye is composed of 12 PRs, four of which express blue-sensitive rhodopsin5 (rh5) while the other eight contain green-sensitive rh6. This is similar to the 30:70 ratio of adult blue and green R8 cells. However, the stochastic choice of adult color PRs and the bistable loop of the warts and melted tumor suppressor genes that unambiguously specify rh5 and rh6 in R8 PRs are not involved in specification of larval PRs. Instead, primary PR precursors signal via EGFR to surrounding tissue to develop as secondary precursors, which will become Rh6-expressing PRs. EGFR signaling is required for the survival of the Rh6 subtype. Primary precursors give rise to the Rh5 subtype. Furthermore, the combinatorial action of the transcription factors Spalt, Seven-up, and Orthodenticle specifies the two PR subtypes. Therefore, even though the larval PRs and adult R8 PRs express the same rhodopsins (rh5 and rh6), they use very distinct mechanisms for their specification.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Genes Dev.
Title	Genes & Development
Publication Year	1987-
ISBN/ISSN	0890-9369
Data from Reference
Aberrations (1)
	Df(2L)32FP-5
Alleles (24)
	BacA\p35^Scer\UAS.cHa Ecol\lacZ^Scer\UAS.cUa Ecol\lacZ^svp-3 Egfr^DN.Scer\UAS Hsap\HIST2H2BE^{Scer\UAS.T:Avic\GFP-YFP} melt^D1 melt^Scer\UAS.cTa Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} oc^uvi salm¹⁶ salm^Scer\UAS.cKa Scer\GAL4^ato.3.6 Scer\GAL4^NP0724 Scer\GAL4^oc.PC Scer\GAL4^salm-R7T3.8 Scer\GAL4^sev.EP Scer\GAL4^so-7.GAL4 svp¹ svp^Scer\UAS.cKa tll¹ tll^l49 tll^unspecified wts^P1 wts^{Scer\UAS.X.T:Hsap\MYC}
Constructs (13)
	P{ato-GAL4.3.6} P{GAL4} P{oc-GAL4.C} P{sevEP-GAL4.B} P{UAS-Egfr.DN} P{UAS-H2B-T:Avic\GFP-YFP} P{UAS-lacZ.U} P{UAS-mCD8::GFP.L} P{UAS-melt.T} P{UAS-p35.H} P{UAS-salm.K} P{UAS-svp1.K} P{UAS-wts.X.MYC}
Genes (22)
	ato BacA\p35 chp Ecol\lacZ Egfr elav Fas2 Hsap\HIST2H2BE melt Mmus\Cd8a ninaE Nrt oc Rh3 Rh4 Rh5 Rh6 salm Scer\GAL4 svp tll wts
Insertions (4)
	P{GawB}salm^R7T3.8 P{GawB}so^7.GAL4 P{GawB}svp^NP0724 P{HZ}svp³