Reference Report

Reference
Citation	Zahedi, B., Shen, W., Xu, X., Chen, X., Mahey, M., Harden, N. (2008). Leading edge-secreted Dpp cooperates with ACK-dependent signaling from the amnioserosa to regulate myosin levels during dorsal closure. Dev. Dyn. 237(10): 2936--2946. (Export to RIS)
FlyBase ID	FBrf0205999
Publication Type	Research paper
PubMed ID	18816840
PubMed Abstract	Dorsal closure of the Drosophila embryo is an epithelial fusion in which the epidermal flanks migrate to close a hole in the epidermis occupied by the amnioserosa, a process driven in part by myosin-dependent cell shape change. Dpp signaling is required for the morphogenesis of both tissues, where it promotes transcription of myosin from the zipper (zip) gene. Drosophila has two members of the activated Cdc42-associated kinase (ACK) family: DACK and PR2. Overexpression of DACK in embryos deficient in Dpp signaling can restore zip expression and suppress dorsal closure defects, while reducing the levels of DACK and PR2 simultaneously using mutations or amnioserosa-specific knock down by RNAi results in loss of zip expression. ACK function in the amnioserosa may generate a signal cooperating with Dpp secreted from the epidermis in driving zip expression in these two tissues, ensuring that cell shape changes in dorsal closure occur in a coordinated manner.
DOI	10.1002/dvdy.21722
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Secondary IDs
Language of Publication	English
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Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Dev. Dyn.
Title	Developmental Dynamics
Publication Year	1992-
ISBN/ISSN	1058-8388
Data from Reference
Aberrations (1)
	Df(3L)Ack^52a
Alleles (17)
	Ack^10b Ack^29b Ack⁸⁶ Ack^KD.Scer\UAS Ack^NIG.14992R Ack^Scer\UAS.cSa Ack-like^c02472 Ack-like^NIG.3969R dpp^hr27 dpp^hr92 dpp^{Scer\UAS.T.T:Avic\GFP-EGFP} Scer\GAL4^c381 Scer\GAL4^hs.PB Scer\GAL4^LE Scer\GAL4^prd.RG1 tkv⁷ tkv^TAJ3
Constructs (7)
	P{?SUPor-P} P{GAL4-prd.F} P{NIG.3969R} P{NIG.14992R} P{UAS-Ack.KD} P{UAS-Ack.S} P{UAS-dpp.GFP.T}
Genes (13)
	Ack Ack-like Cap-G Chd64 Dad dpp Fit1 Mad salm Scer\GAL4 tkv TppII zip
Insertions (5)
	P{?SUPor-P}Ack^10b P{GAL4}LE P{SUPor-P}KG00869 P{UAS-tkv}TAJ3 PBac{PB}Ack-like^c02472
Natural transposons (1)
	P-element