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Citation
Szafer-Glusman, E., Giansanti, M.G., Nishihama, R., Bolival, B., Pringle, J., Gatti, M., Fuller, M.T. (2008). A role for very-long-chain fatty acids in furrow ingression during cytokinesis in Drosophila spermatocytes.  Curr. Biol. 18(18): 1426--1431.
FlyBase ID
FBrf0206098
Publication Type
Research paper
Abstract

Cell shape and membrane remodeling rely on regulated interactions between the lipid bilayer and cytoskeletal arrays at the cell cortex. During cytokinesis, animal cells build an actomyosin ring anchored to the plasma membrane at the equatorial cortex. Ring constriction coupled to plasma-membrane ingression separates the two daughter cells. Plasma-membrane lipids influence membrane biophysical properties such as membrane curvature and elasticity and play an active role in cell function, and specialized membrane domains are emerging as important factors in regulating assembly and rearrangement of the cytoskeleton. Here, we show that mutations in the gene bond, which encodes a Drosophila member of the family of Elovl proteins that mediate elongation of very-long-chain fatty acids, block or dramatically slow cleavage-furrow ingression during early telophase in dividing spermatocytes. In bond mutant cells at late stages of division, the contractile ring frequently detaches from the cortex and constricts or collapses to one side of the cell, and the cleavage furrow regresses. Our findings implicate very-long-chain fatty acids or their derivative complex lipids in allowing supple membrane deformation and the stable connection of cortical contractile components to the plasma membrane during cell division.

PubMed ID
PubMed Central ID
PMC2577570 (PMC) (EuropePMC)
Related Publication(s)
Note

Cytokinesis: a new lipid aboard the raft.
Alford and Burgess, 2008, Curr. Biol. 18(19): R921--R923 [FBrf0215645]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Curr. Biol.
    Title
    Current Biology
    Publication Year
    1991-
    ISBN/ISSN
    0960-9822
    Data From Reference
    Alleles (9)
    Gene Groups (1)
    Genes (25)
    Natural transposons (1)
    Transgenic Constructs (3)