Reference Report

Reference
Citation	Ueno, K., Kidokoro, Y. (2008). Adenylyl cyclase encoded by AC78C participates in sugar perception in Drosophila melanogaster. Europ. J. Neurosci. 28(10): 1956--1966. (Export to RIS)
FlyBase ID	FBrf0206345
Publication Type	Research paper
PubMed ID	19046378
PubMed Abstract	In gustatory receptor neurons (GRNs) in Drosophila melanogaster, Gr5a and one of the Gr64s encode sugar receptors with seven transmembrane domains. Previously, we have shown that the responses to various sugars are depressed in DGsalpha mutant flies (Ueno et al., 2006). Because DGsalpha is a homolog of Gs, we hypothesized that the sugar receptors are coupled to adenylyl cyclase (AC) in Drosophila. The aim of this study was to identify the AC that participates in sugar perception. Here, we found that an AC inhibitor, MDL-12330A, depressed the response in GRNs to trehalose as well as sucrose; that an AC gene, AC78C, was expressed in the sugar-sensitive GRNs; that RNAi against AC78C depressed the electrical response in GRNs to sucrose; and that the sugar response in GRNs, as well as sugar intake in a behavioral assay in an AC78C mutant, was depressed at low sugar concentrations. We conclude that AC78C, via cAMP, participates in the sugar-taste signaling pathway at the low concentration range.
DOI	10.1111/j.1460-9568.2008.06507.x
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Secondary IDs
Language of Publication	English
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Publication Type	Journal
Abbreviation	Europ. J. Neurosci.
Title	European Journal of Neuroscience
Publication Year	1989-
ISBN/ISSN	0953-816X
Data from Reference
Aberrations (2)
	Df(3L)BSC449 Df(3L)Pc-MK
Alleles (7)
	Ac78C^BG01408 Ac78C^{dsRNA.Scer\UAS} Ac78C^Δ32 ACXE^{dsRNA.Scer\UAS} Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} rpr^Scer\UAS.C Scer\GAL4^Gr5a.PU
Constructs (5)
	P{Gr5a-GAL4.U} P{UAS-Ac78C.dsRNA.2914-3376} P{UAS-ACXE.dsRNA.473-981} P{UAS-mCD8::GFP.L} P{UAS-rpr.C}
Genes (21)
	Ac3 Ac13E Ac76E Ac78C ACXA ACXB ACXC ACXD ACXE asparagine-synthetase CG32301 CG32305 CG42514 CG43373 chb Gr5a Gαs Mmus\Cd8a rpr rut Scer\GAL4
Insertions (1)
	P{GT1}BG01408
Natural transposons (1)
	P-element