Reference Report

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Citation	Castro, A.J., Grisolia, C.K., de Araújo, B.C., Dias, C.D., Dutra, E.S., Nepomuceno, J.C. (2008). Recombinogenic effects of the aqueous extract of pulp from pequi fruit (Caryocar brasiliense) on somatic cells of Drosophila melanogaster. Genet. Mol. Res. 7(4): 1375--1383. (Export to RIS)
FlyBase ID	FBrf0206378
Publication Type	Research paper
PubMed ID	19065773
PubMed Abstract	Caryocar brasiliense Camb. is a tree popularly known in Central Brazil as pequi. Its fruit contains carotenes, retinols, vitamin C, and polyphenols. These compounds possess antioxidant properties preventing excessive free radical formation and modulating the genotoxicity of physical and chemical agents in the body. However, at high concentrations these compounds can have recombinogenic and mutagenic effects, because they can act as pro-oxidants. We examined the genotoxic effects of aqueous extracts of pequi pulp on wing spots of Drosophila melanogaster using the somatic mutation and recombination test (SMART). SMART was applied to a standard cross and to a high bioactivation cross. Two types of descendants were obtained from these crosses: marked-heterozygous (mwh + / + flr3) and balancer-heterozygous (mwh + / + TM3, Bds). Seventy-two-hour larvae from both crosses were treated with pequi pulp extract at 1, 5 and 10%. The extract increased significantly the frequency of mutant spots when compared with the negative control. Recombinogenic effects were also observed in the mwh/TM3 descendants.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genet. Mol. Res.
Title	Genetics and molecular research
Publication Year	2002-
ISBN/ISSN	1676-5680
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	flr mwh