Reference Report

Reference
Citation	Benton, R., Vannice, K.S., Gomez-Diaz, C., Vosshall, L.B. (2009). Variant ionotropic glutamate receptors as chemosensory receptors in Drosophila. Cell 136(1): 149--162. (Export to RIS)
FlyBase ID	FBrf0206496
Publication Type	Research paper
PubMed ID	19135896
PubMed Abstract	Ionotropic glutamate receptors (iGluRs) mediate neuronal communication at synapses throughout vertebrate and invertebrate nervous systems. We have characterized a family of iGluR-related genes in Drosophila, which we name ionotropic receptors (IRs). These receptors do not belong to the well-described kainate, AMPA, or NMDA classes of iGluRs, and they have divergent ligand-binding domains that lack their characteristic glutamate-interacting residues. IRs are expressed in a combinatorial fashion in sensory neurons that respond to many distinct odors but do not express either insect odorant receptors (ORs) or gustatory receptors (GRs). IR proteins accumulate in sensory dendrites and not at synapses. Misexpression of IRs in different olfactory neurons is sufficient to confer ectopic odor responsiveness. Together, these results lead us to propose that the IRs comprise a novel family of chemosensory receptors. Conservation of IR/iGluR-related proteins in bacteria, plants, and animals suggests that this receptor family represents an evolutionarily ancient mechanism for sensing both internal and external chemical cues.
DOI	10.1016/j.cell.2008.12.001
Related Publication(s)
Supplementary material	Supplemental Experimental Procedures. [FBrf0207607]
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (2)
	Df(2L)M36F-S6 Df(3R)p13
Alleles (12)
	amos¹ ato¹ Ir25a¹ Ir25a² Ir31a^Scer\UAS.cBa Ir75d^Scer\UAS.cBa Ir76a^Scer\UAS.cBa Ir84a^Scer\UAS.cBa Ir92a^Scer\UAS.cBa Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Scer\GAL4^Ir76a.PB Scer\GAL4^Or35a.PF
Constructs (8)
	P{Ir76a-GAL4.PB} P{Or35a-GAL4.F} P{UAS-Ir31a.B} P{UAS-Ir75d.B} P{UAS-Ir76a.B} P{UAS-Ir84a.B} P{UAS-Ir92a.B} P{UAS-mCD8::GFP.L}
Genes (86)
	amos ato brp CG3822 CG5621 CG9935 CG11155 clumsy elav eys GluRIA GluRIB GluRIIA GluRIIB GluRIIC GluRIID GluRIIE Ir7a Ir7b Ir7c Ir7d Ir7e Ir7f Ir7g Ir8a Ir10a Ir11a Ir20a Ir21a Ir25a Ir31a Ir40a Ir41a Ir47a Ir48a Ir48b Ir48c Ir51a Ir51b Ir52a Ir52b Ir52c Ir52d Ir54a Ir56a Ir56b Ir56c Ir56d Ir60a Ir60b Ir60c Ir60d Ir60e Ir62a Ir64a Ir67a Ir67b Ir67c Ir68a Ir68b Ir75a Ir75b Ir75c Ir75d Ir76a Ir76b Ir84a Ir85a Ir87a Ir92a Ir93a Ir94a Ir94b Ir94c Ir94d Ir94e Ir94f Ir94g Ir94h Ir100a Mmus\Cd8a Nmdar1 Nmdar2 Or35a Orco Scer\GAL4
Transcripts (2)
	Scer\GAL4^Ir76a.PBRA Scer\GAL4^Or35a.PFRA