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Citation
Benton, R., Vannice, K.S., Gomez-Diaz, C., Vosshall, L.B. (2009). Variant ionotropic glutamate receptors as chemosensory receptors in Drosophila.  Cell 136(1): 149--162.
FlyBase ID
FBrf0206496
Publication Type
Research paper
Abstract

Ionotropic glutamate receptors (iGluRs) mediate neuronal communication at synapses throughout vertebrate and invertebrate nervous systems. We have characterized a family of iGluR-related genes in Drosophila, which we name ionotropic receptors (IRs). These receptors do not belong to the well-described kainate, AMPA, or NMDA classes of iGluRs, and they have divergent ligand-binding domains that lack their characteristic glutamate-interacting residues. IRs are expressed in a combinatorial fashion in sensory neurons that respond to many distinct odors but do not express either insect odorant receptors (ORs) or gustatory receptors (GRs). IR proteins accumulate in sensory dendrites and not at synapses. Misexpression of IRs in different olfactory neurons is sufficient to confer ectopic odor responsiveness. Together, these results lead us to propose that the IRs comprise a novel family of chemosensory receptors. Conservation of IR/iGluR-related proteins in bacteria, plants, and animals suggests that this receptor family represents an evolutionarily ancient mechanism for sensing both internal and external chemical cues.

PubMed ID
PubMed Central ID
PMC2709536 (PMC) (EuropePMC)
Related Publication(s)
Note

A new family of odorant receptors in Drosophila.
Spletter and Luo, 2009, Cell 136(1): 23--25 [FBrf0206515]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference